Effects of sclerostin antibody on bone healing

Table 1 The efficacy of sclerostin antibody for bone healing has been demonstrated in several reports with animal models

Animal model	Bone	Bone injury model	Dosage, frequency	Major findings	Ref.
Mouse	Tibia	Osteotomy	100 mg/kg, 1/wk	BV/TV↑, strength↑	[36]
Rat	Femur	Fracture	25 mg/kg, 2/wk	Callus↑, BMC↑, BV/TV↑, strength↑	[37]
Cynomolgus monkey	Fibula	Osteotomy	30 mg/kg, 1/2 wk	Callus↑, BMC↑, strength↑	[37]
Rat	Femur	Ablation	25 mg/kg, 2/wk	Fixation strength↑, cortical thickness↑, BV/TV↑	[40]
Rat	Femur	Fracture	25 mg/kg, 2/wk	BMD↑, BV/TV↑, strength↑, MS/BS↑, BFR/BS↑	[38]
Rat	Femur	Osteotomy	25 mg/kg, 2/wk	Callus↑, BMD↑, BV/TV↑, strength↑, bone area↑, cartilage↓	[39]
Mouse	Femur	Fracture	25 mg/kg, 2/wk	BV/TV↑, BMC↑	[41]
T1DM mouse	Femur	Fracture	25 mg/kg, 2/wk	BV/TV↑, BMC↑	[41]
Rat	Femur	Osteotomy	25 mg/kg, 2/wk	Mature callus↑, BMC↑, BMD↑, strength↑	[42]
Rat	Tibia	Metaphyseal screw	25 mg/kg, 2/wk	Pull-out strength↑, bone volume surrounding screw↑	[43]
Rat	Femur	Distraction osteogenesis	25 mg/kg, 2/wk	Union rate→, (united bones) strength↑, bone volume↑	[45]
Rat	Femur	Critical defect	25 mg/kg, 2/wk	Union rate↑, bone formation markers↑	[46]
Mouse	Femur	Osteotomy rigid fix	25 mg/kg, 2/wk	Periosteal and/or intracortical bridging→, endosteal bridging↑	[48]
Mouse	Femur	Osteotomy semi-rigid fix	25 mg/kg, 2/wk	Periosteal and/or intracortical bridging→, endosteal bridging↑	[48]

T1DM: Type 1 diabetes mellitus; BV/TV: Bone volume to total bone volume ratio; BMC: Bone mineral content; BMD: Bone mineral density; MS/BS: Mineralizing surface rate; BFR/BS: Bone formation rate.