Zicaro JP, Garcia-Mansilla I, Zuain A, Yacuzzi C, Costa-Paz M. Has platelet-rich plasma any role in partial tears of the anterior cruciate ligament? Prospective comparative study. World J Orthop 2021; 12(6): 423-432 [PMID: 34189080 DOI: 10.5312/wjo.v12.i6.423]
Corresponding Author of This Article
Ignacio Garcia-Mansilla, MD, Academic Research, Surgeon, Knee division, Hospital Italiano de Buenos Aires, Peron 4190, Buenos Aires 1181, Argentina. ignaciogmansilla@gmail.com
Research Domain of This Article
Orthopedics
Article-Type of This Article
Prospective Study
Open-Access Policy of This Article
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World J Orthop. Jun 18, 2021; 12(6): 423-432 Published online Jun 18, 2021. doi: 10.5312/wjo.v12.i6.423
Table 1 Details of the baseline and platelet rich plasma platelets and white cells concentrations
Initial platelet concentration
PRP
%
Platelets, median (IQR)
264500 (247000-278000)
1125500 (1088000-1340500)
444 (407-519)
WC, median (IQR)
5200 (4790-6480)
600 (220-810)
10 (3-15)
Table 2 Demographic data
Group 1, n = 21
Group 2, n = 19
P value
Age in yr, median (IQR)
25 (22-39)
31 (26-34)
0.54
Male, n (%)
15 (71.4)
19 (100)
0.02
FU in mo, median (IQR)
25 (18-36)
25 (18-30)
0.86
MRI tear location:
Proximal, n (%)
10 (48)
12 (63)
Mid-substance, n (%)
11 (52)
7 (27)
Table 3 Results at final follow-up
Baseline
Group 1, n = 21
Group 2, n = 19
P value
Lysholm score, median (IQR)
69.5 (43.0-85.0)
54.0 (41.0-77.0)
0.41
IKDC score, median (IQR)
58.5 (44.0-60.0)
58.0 (44.0-60.0)
0.84
TAL, mean ± SD
6.90 ± 1.07
6.70 ± 1.18
0.65
At final follow-up
Lysholm score, median (IQR)
80 (75-90)
80 (73-86)
0.53
IKDC score, median (IQR)
77 (71-89)
71 (70-79)
0.33
TAL, mean ± SD
6.70 ± 1.52
6.50 ± 1.61
0.7
RTS rate, n (%)
20 (95)
18 (95)
0.9
Time to RTS in mo, mean ± SD
3.8 ± 0.8
4.3 ± 1.2
0.09
Failure rate, n (%)
7 (33)
6 (31)
0.9
Table 4 Magnetic resonance image Van Meer classification at baseline and at 6 mo
MRI Van Meer classification
Group 1
Group 2
P value
Baseline MRI, mean ± SD
6.1 ± 1.7
6.2 ± 2.4
0.97
MRI at 6 mo follow-up, mean ± SD
3.4 ± 2.9
3.6 ± 2.5
0.82
Citation: Zicaro JP, Garcia-Mansilla I, Zuain A, Yacuzzi C, Costa-Paz M. Has platelet-rich plasma any role in partial tears of the anterior cruciate ligament? Prospective comparative study. World J Orthop 2021; 12(6): 423-432