Long-term effect of intrathecal baclofen treatment on bone health and body composition after spinal cord injury: A case matched report

Table 1 Physical and spinal cord injury characteristics of the case report and case-match (1 and 2)

Characteristics	Case report	Case match 1	Case match 2
Age (yr)	46	25	44
Weight (kg)	44.8	58	53.5
Height (cm)	160.2	185.4	183
BMI (kg/m2)	17.5	16.9	16
Gender	Male	Male	Male
Ethnicity	White	White	White
Level of injury	C6	C7	C7
Level of paralysis	Tetraplegia	Tetraplegia	Tetraplegia
Time since injury (yr)	20	2	13
AIS classification	A	B	A

Case match 1 was included to account for the lack of initial DXA scan for the case report at the time of IBT implantation. AIS: American Spinal Injury Association impairment scale; BMI: Body mass index.

Table 2 Bone mineral density and bone mineral content for knee metaphysis and bone epiphysis of distal femur and proximal tibia in a case report with intrathecal baclofen treatment implantation and the case-matches with complete spinal cord injury

Region	RDFM	RPTM	LDFM	LPTM	RDFE	RPTE	LDFE	LPTE
Knee BMC
Case report	3.97	4.29	4.11	4.07	5.73	4.66	6.94	4.58
Case match 1	8.49	8.32	7.89	9.2	15.68	12.4	16.15	12.71
% change case to match 1	113.3	93.9	91.9	126.0	173.6	166.0	132.7	177.5
Case match 2	5.13	3.21	5.28	4.79	9.79	5.12	11.66	6.63
% change case to match 2	29.2	-25.1	28.4	17.7	70.8	9.8	68.0	44.7
Knee BMD
Case report	0.257	0.484	0.267	0.404	0.277	0.248	0.354	0.247
Case match 1	0.605	0.665	0.585	0.731	0.605	0.479	0.634	0.498
% change case to match 1	135.4	37.4	119.1	80.9	118.4	93.1	79.09	101.6
Case match 2	0.371	0.263	0.376	0.362	0.435	0.246	0.487	0.286
% change case to match 2	44.3	-45.6	40.8	-10.4	57.0	-0.8065	37.6	15.8

% change is the percentage changes in either bone mineral density or bone mineral content between the case report and either the case match 1 [2 years post- post-spinal cord injury (SCI)] or the case-match 2 (13-years post-SCI). BMC: Bone mineral content; BMD: Bone mineral density; RDFM: Right distal femur metaphysis; RPTM: Right proximal tibia metaphysis; LDFM: Left distal femur metaphysis; LPTM: Left proximal tibia metaphysis; RDFE: Right distal femur epiphysis; RPTE: Right proximal tibia epiphysis; LDFE: Left distal femur epiphysis; LPTE: Left proximal tibia epiphysis.

Table 3 Total body and leg composition assessments using dual-energy X-ray in a case report with IBT implantation and case-matches with complete spinal cord injury

Region	%Fat	%Lean	LM (g)	BMC (g)	TM (kg)	Mass (kg)
Total body composition
Case report	27.3	68.89362	29142	1597	42.3
Case match 1	21.4	74.34251	43193	2468	58.1
% change case to match 1	-5.9	5.4	48.2	54.5	37.3
Case match 2	24.2	72.2	39205	1938	54.3
% change case to match 2	-3.1	3.3	34.5	21.3	28.3
Leg composition
Case report	39.2	57.8	6714	356		11.6
Case match 1	28.6	67.9	12646	646		18.6
% change case to match 1	-27.1	17.4	88.3	81.4		60.3
Case match 2	32.7	64.7	11591	482		17.9
% change case to match 2	-16.5	11.8	72.6	35.3		54.3

% change is the percentage changes in either bone mineral density or bone mineral content between the case report and case-matches. %Fat: Percentage of fat mass; %Lean: Percentage of lean mass; LM: Lean mass; BMC: Bone mineral content; TM: Total mass.