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Copyright ©The Author(s) 2019.
World J Orthop. Feb 18, 2019; 10(2): 63-70
Published online Feb 18, 2019. doi: 10.5312/wjo.v10.i2.63
Table 1 Diagnostic criteria for post-implantation metal hypersensitivity[25]
Major criteria
Eruption overlying the metal implant
Positive patch test reaction to a metal used in the implant
Complete recovery after removal of the offending implant
Chronic dermatitis beginning weeks to months after metallic implantation
Minor criteria
Unexplained pain and/or failure of the offending implant
Dermatitis reaction is resistant to therapy
Morphology consistent with dermatitis (erythema, induration, papules, vesicles)
Systemic allergic dermatitis reaction
Histology consistent with allergic contact dermatitis
Positive in vitro test to metals (e.g., lymphocytes transformation test)