Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis

Table 1 Patient demographics and laboratory results

	Aseptic	Septic	P value	Number missing date
Number of patients	10	10
Age (yr) +/- SD	54.8 +/- 20.0	54.6 +/- 12.1	0.98	0
Sex (male)	7	7	0.99	0
Serum WBC (k cells/mm3)	11.7 +/- 4.0	13.4 +/- 8.2	0.57	1
Serum ESR (mm/hr)	58.4 +/- 35.2	80.4 +/- 50.7	0.33	4
Serum CRP (mg/dL)	16.1 +/- 10.1	19.6 +/- 12.8	0.53	2
Synovial WBC (k cells/mm3)	39.8 +/- 62.8	42.8 +/- 46.5	0.91	1
Synovial % PMNs	84.8 +/- 13.7	80.6 +/- 30.2	0.73	2
Sepsis MetaScore	-0.33 +/- 0.63	1.1 +/- 1.3	P = 0.008	0

WBC: White blood cell; ESR: Erythrocyte sedimentation rate; CRP: C-reactive protein; PMNs: Polymorphonuclear cells.

Table 2 Multivariate logistic regression analysis for the prediction of infection

	Effect estimate	Std. Error	t value	P value
Intercept	0.833	0.577	1.443	0.199
CRP	-0.022	0.015	-1.488	0.187
ESR	-0.001	0.004	-0.213	0.839
WBC	-0.001	0.024	-0.043	0.967
synovial WBC	0.000	0.000	0.438	0.677
synovial % PMN	-0.001	0.007	-0.149	0.887
Sepsis metascore	0.595	0.210	2.831	0.030
Residual standard error: 0.4478 on 6 degrees of freedom
Multiple R-squared: 0.6275			Adjusted R-squared: 0.2551
F-statistic: 1.685

WBC: White blood cell; ESR: Erythrocyte sedimentation rate; CRP: C-reactive protein; PMN: Polymorphonuclear cells.