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World J Orthop. Dec 18, 2016; 7(12): 785-792
Published online Dec 18, 2016. doi: 10.5312/wjo.v7.i12.785
Lessons learned from study of congenital hip disease in adults
George Hartofilakidis, Kalliopi Lampropoulou-Adamidou, Laboratory for the Research of Musculoskeletal System “Th. Garofalidis”, Medical School, University of Athens, General Hospital of Athens KAT, Athens 14561, Greece
Author contributions: Professor Hartofilakidis G contributed to the conception of the study; both authors were involved in the design of the study and acquisition of the data, drafting the article and final approval of the version of the article to be published.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: George Hartofilakidis, MD, FACS, Professor Emeritus, Laboratory for the Research of Musculoskeletal System “Th. Garofalidis”, Medical School, University of Athens, General Hospital of Athens KAT, 10 Athinas Str., Kifissia, Athens 14561, Greece. geo@hart7.com
Telephone: +30-21-03610990
Received: April 14, 2016
Peer-review started: April 18, 2016
First decision: June 14, 2016
Revised: June 29, 2016
Accepted: August 27, 2016
Article in press: August 29, 2016
Published online: December 18, 2016
Processing time: 236 Days and 22.4 Hours

Abstract

Orthopaedic surgeons specialising in adult hip reconstruction surgery often face the problem of osteoarthritis secondary to congenital hip disease (CHD). To achieve better communication among physicians, better treatment planning and evaluation of the results of various treatment options, an agreed terminology is needed to describe the entire pathology. Furthermore, a generally accepted classification of the deformities is necessary. Herein, the authors propose the use of the term “congenital hip disease” and its classification as dysplasia, low dislocation and high dislocation. Knowledge of the CHD natural history facilitates comprehension of the potential development and progression of the disease, which differs among the aforementioned types. This can lead to better understanding of the anatomical abnormalities found in the different CHD types and thus facilitate preoperative planning and choice of the most appropriate management for adult patients. The basic principles for improved results of total hip replacement in patients with CHD, especially those with low and high dislocation, are: Wide exposure, restoration of the normal centre of rotation and the use of special techniques and implants for the reconstruction of the acetabulum and femur. Application of these principles during total hip replacement in young female patients born with severe deformities of the hip joint has led to radical improvement of their quality of life.

Key Words: Congenital hip disease; Low dislocation of the hip; Hartofilakidis classification; Dysplasia of the hip; High dislocation of the hip; Total hip replacement; Trochanteric osteotomy; Restoration of the normal centre of rotation; Femoral shortening; Patients’ satisfaction

Core tip: This review is based on the knowledge and experience acquired in the long course of the senior author’s surgical practice on the complex problem of congenital deformities of the hip in adults.



INTRODUCTION

Congenital deformities of the hip are the main cause of secondary joint osteoarthritis (OA). Depending on the severity of the deformity, undiagnosed patients or those treated insufficiently in infancy face the problem of OA earlier or later in their adult life.

Initially, before the introduction of total hip replacement (THR), we were treating adult patients with different types of osteotomies, without having enough knowledge of the pathological anatomy and the natural history of the underlying deformity. This explains why the results of osteotomies were not always satisfactory. Later, when we started to treat these patients with THR, we realised that the anatomy of the joint differs between patients, thus requiring adjustment of the surgical technique. Since then, the complex problem of congenital hip deformities became one of the main scientific interests of the senior author (GH). Lessons learned, in the long course of this experience, are summarised in this review article.

Lesson 1

The first lesson involves the understanding of the nature of the hip deformities present at birth. The terms used for these deformities were mostly misleading, causing misunderstandings and confusion. We have been concerned about the term “developmental dysplasia of the hip” (DDH) for two reasons: (1) The term “developmental” is not descriptive of the congenital origin of the deformity; and (2) An indiscriminate use of the term “dysplasia” is not in agreement with the variety of the underlying pathology. Therefore, we recommend the use of the term “congenital hip disease” (CHD) for the entire spectrum of related deformities. These deformities are congenital in nature and have the potential to develop.

Furthermore, we recognized that for better communication, planning of treatment and evaluation of the results of different treatments, a classification system of general acceptance must be used. Weinstein had classified CHD in infancy in three radiographic types: (1) dysplasia (inclination of the acetabulum with centralized ossification centre - Shenton’s line intact); (2) subluxation (subluxed ossification centre - Shenton’s line broken); and (3) complete dislocation (ossification centre outside the acetabulum) (Figure 1). Based on that classification, we identified in adults three different CHD types of increasing severity: (1) dysplasia; (2) low dislocation; and (3) high dislocation. Depending on the type, adjustment of our surgical technique during THR is required. In dysplasia, the femoral head is contained within the original acetabulum. In low dislocation, the femoral head articulates with a false acetabulum that partially covers the true acetabulum. In high dislocation, the femoral head is migrated superiorly and posteriorly to the hypoplastic true acetabulum. The proximal part of the femur, in dysplasia, is normal. In low dislocation, the femoral neck is short, and shorter still in a high dislocation, with excessive anteversion. The diaphysis, in high dislocation, is hypoplastic with excessive narrowing of the femoral canal and has thin cortices (Figure 2).

Figure 1
Figure 1 Drawings of the three types of the disease in infants.
Figure 2
Figure 2 Drawings and three dimensional-computed tomography images of the 3 types of congenital hip disease in adults. The black-colored areas in dysplasia represents the large osteophyte that covers the acetabular fossa and the medial marginal osteophyte of the femoral head (capital drop), and in low dislocation it the inferior part of the false acetabulum that is an osteophyte which begins at the level of the superior rim of the true acetabulum.

Later, in a refinement of our classification system, we further subdivided low and high dislocation. Low dislocation was subdivided into B1 and B2 subtypes, when the false acetabulum covers more or less than 50% of the true acetabulum, respectively. High dislocation was subdivided into C1 and C2 subtypes, depending on the presence or the absence of a false acetabulum, respectively (Figures 3 and 4). The lesson learned by using this classification system is that “better comprehension of the pathologic anatomy and the specific characteristics of these hips, makes their THR reconstruction easier and more successful”[1-9].

Figure 3
Figure 3 Images illustrating the two subtypes of low dislocation: B1 and B2. Three points must be recognised on radiographs: (A) the superior limit of the true acetabulum; (B) the inferior point of the teardrop; (C) the most inferior point of the false acetabulum. Three dimensional-computed tomography scans may help to determine the superior limit of the true acetabulum, when it is not clear in plain radiographs. Asterisks depict false acetabulum and arrowheads true acetabulum.
Figure 4
Figure 4 Three dimensional-computed tomography scans of the two subtypes of high dislocation. Arrows indicate the true and asterisks the false acetabulum.
Lesson 2

The second lesson learned is that knowledge of the natural history of CHD facilitates comprehension of the potential development and progression of the disease, which differs among the three types. This can lead to better understanding of the anatomical abnormalities found in the different types, thus facilitating preoperative planning and choice of the most appropriate management for adult patients.

In our country, before the introduction of screening systems, the majority of infant dysplastic hips remained undiagnosed until the onset of symptoms, usually at the third decade of a patient’s life. Degenerative changes progress slowly since that time and, usually, THR can be postponed until the age of 45-50 years. Patients with low dislocation, who had not received previous treatment in infancy, limp since childhood and experience pain later in their lives, usually at the age of 25-30 years. In these cases, degenerative changes develop within the false acetabulum and THR, usually becomes necessary earlier than in dysplastic hips. Patients with high dislocation and no previous treatment also limp since early childhood. Limping is more severe in patients with unilateral involvement. Natural history depends on the presence or absence of a false acetabulum. In patients with a false acetabulum pain starts early, usually around 30 years of age, while in patients without a false acetabulum pain starts much later, around the age of 40-45 years, as a consequence of muscle fatigue (Figures 5-7). In unilateral involvement, the leg-length discrepancy ranges between 4-10 cm and increases the disability of the patient. Also, the ipsilateral knee presents valgus deformity, sometimes severe, and the spine thoracolumbar scoliosis.

Figure 5
Figure 5 Development of dysplastic hips. A: At the age of 3 years, when the child was first seen by her physician. An abduction frame was applied for 6 mo; B: At the age of 35 years, the patient had the first symptoms, pain and limping, due to the development of secondary hip osteoarthritis.
Figure 6
Figure 6 Radiographs and diagrams of a female patient with subluxation of the left hip in infancy, subsequently developed to low dislocation. A: At the age of 2 years; B: Image, when the patient was 37 years old.
Figure 7
Figure 7 Images illustrating the case of a female patient with bilateral high dislocation. A: Radiograph at the age of 2 years; B: Radiograph, at the age of 33 years, when the patient was consulted for bilateral total hip replacements.

The indication for a THR not only depends on the degree of pain and disability, but also includes emotional parameters, given that these patients are young females with an active and productive life[10,11].

Lesson 3

Another lesson learned is that THR is a difficult operation and should be performed by experienced surgeons and only when there is an absolute indication based on the patient’s symptoms, psychological impact, clinical findings and the potential of disease development; “Not to early, not to late”. Several technical details should be considered[9,12-17].

Transtrochanteric approach: Wide exposure is essential for the reconstruction, especially of hips with low and high dislocation. The lateral transtrochanteric approach was introduced by Charnley, who suggested that it would facilitate the access to the joint and the reconstruction of the disturbed anatomy of the acetabulum and the proximal femur. Additionally, lateral reattachment of the trochanter increases the abductor lever arm and minimises the reactive forces acting on the acetabulum. Four categories of the trochanteric reattachment are recognised: (1) reattachment at the original bed of trochanteric osteotomy; (2) distal reattachment in relation to its original bed, the trochanter having contact with the distal part of the original bed; (3) reattachment on the lateral femoral cortex in cases where the femoral neck was resected to the level of the lesser trochanter; and (4) reattachment proximal to its original bed (Figure 8). The ideal reattachment of the trochanter is the distal reattachment retaining contact with the distal part of the original bed. However, this is not always possible mainly due to shortened abductor muscles, an often small and malpositioned trochanter and a lengthened limb[16].

Figure 8
Figure 8 Drawings depicting. A: Reattachment of the trochanter at its original bed; B: Distal reattachment of the trochanter, retaining contact with the distal part of the original bed; C: Reattachment of the trochanter on the lateral femoral cortex; D: Proximal reattachment of the trochanter.

The most common complication of trochanteric osteotomy is the non-union of the trochanteric fragment. Other complications include breakage and migration of the wires, heterotopic ossification and dislocation. We learned that the complications of this exposure were less important than the benefits gained[16].

Restoration of the normal centre of rotation of the joint: Placement of the acetabular component at the level of true acetabulum is essential for restoration of the hip biomechanics and improvement of survival of the prosthesis. However, it is not always possible to achieve bony coverage of the acetabular component at this level. Two alternative techniques have been used to solve this problem. When the reamed acetabulum can provide at least 80% osseous coverage of the implant, we use an uncemented small 40-42 mm metal backed acetabular component. If this is not feasible, the cotyloplasty technique is an effective alternative. Cotyloplasty involves medialization of the acetabular floor through creation of a comminuted fracture of the entire medial wall, impaction of autogenous cancellous morselized bone grafts and implantation of a small, all-polyethylene (PE) implant, usually the offset-bore acetabular cup (Figure 9)[3,9,14]. The main mechanical advantage of this technique is that the weight-bearing area is allowed to shift to beneath the acetabular roof, while adequate anterior and posterior coverage of the cup is achieved. Moreover, the host-graft interface is biologically active, which may ensure incorporation of the graft and the anatomical placement of the cup. This, combined with carefully controlled medialization optimizes the mechanical environment and influences the long-term survival of the artificial hip.

Figure 9
Figure 9 Cotyloplasty technique. A: Comminuted fracture of the entire medial wall; B: Large amount of cancellous morselised graft placed between the fragments of the acetabular floor, onto the periosteum; C: Grafts moulded with a hemispherical pusher; D): Final appearance: I: Anchorage hole; II: Internal layer of the periosteum; III: Autogenous morselised graft; IV: Fragments of the acetabular floor; V: Cement mantle; VI: Offset-bore acetabular component.

On the other hand, augmentation of superior segmental defects with structural autograft or allograft and placement of the acetabular component in the anatomical position had been suggested by Harris et al[18]. Although the short-term results of this technique were excellent, a high failure rate after approximately 12 years has been reported[19]. This may be related to the complex pathological anatomy encountered at the level of the true acetabulum and the abnormal distribution of stresses, combined with the unfavourable long-term biological behaviour of structural grafts[3,9].

Shortening of the femur: For hips with high dislocation, shortening of the femur during THR is inevitable. We favour shortening of the femur by progressive resection of bone at the level of the femoral neck. We argue against leaving the greater trochanter in place and subtrochanteric femoral shortening osteotomy, because, in the majority of hips with high dislocation, the greater trochanter lies above the centre of rotation of the femoral head and its resection and advancement are essential (Figure 10). Besides, subtrochanteric osteotomy resembles an artificial fracture which needs additional osteosynthesis and may subsequently cause undesirable complications[9].

Figure 10
Figure 10 Drawings of the two alternatives of shortening of the femur. A: At the level of femoral neck; B: Distal shortening at the level of femoral shaft.

Special implants: Special small implants are needed. We have been using the Charnley’s offset bore cup in most of our cases. It is an extra small all-PE implant with a 35 mm face diameter, offset articular surface and approximately 10 mm PE thickness at the upper weight-bearing part, equal to that of a conventional socket, that decreases to a few millimetres in the lower part. In cases with a narrow femoral canal and short and anteverted neck, for the reconstruction of the femur we have mostly used the stainless steel Charnley CDH stems with polished surface, monoblock and collarless, and the Harris CDH stem made of CoCr, precoated at the proximal part, modular and with collar[20-22]. Currently new cementless designs are used.

Lesson 4

Females with congenital dislocation of the hip represent a special cohort of patients with a problematic life since birth. These patients are of young age and may have pain, severe limping and deformation, major leg-length discrepancies and several psychological disorders, such as anxiety and depression, since their early childhood. We evaluated the quality of life (QoL) of 82 female patients, with low and high dislocation, followed for a minimum of 12 years after THR using clinical scores and QoL questionnaires. We concluded that THR radically improves their QoL for a long period of time. Even patients who subsequently underwent revisions had enjoyed pain relief and functional improvement for an appreciable period of time[23].

Letters from these patients, many years after surgery, show their satisfaction for the great changes in their physical and psychological status as well as their social and family life. Short excerpts from this communication are the following[24]: “My childhood was a life of torrent. My mother used to tell me that no man is going to love me. She made me feel useless. My life changed after surgeries at the age of 28. I got married and now I have a 15-year-old son. We are a happy family”; “My childhood and teenage life were very difficult, with many complexities and insecurities. I was feeling like a child of an inferior God. I took the decision to have an arthroplasty at the age of 29. Even though it was necessary to be operated again after 11 years, I am now fully active leading a normal life. I am very pleased”; “My life was an Odyssey. At school, the children were making fun of me for being so different to them because of my pelvic deformity and my movements. When I had the arthroplasties in my hips, I was 47 years old. My life changed. I look at the mirror and I do not believe my eyes. People who knew me did not recognize me. Twenty-four years have gone since I was operated and I have a normal life”.

Concluding messages

The most suitable term for the total spectrum of congenital hip deformities is “CHD”, classified in adults into dysplasia (type A), low dislocation (type B) and high dislocation (type C). Types B and C are further subdivided in subtypes B1 and B2, and C1 and C2, respectively, depending on their different anatomic characteristics.

The three types of CHD are the main causes of secondary OA. Degenerative changes develop gradually, usually from the age of 30-35 years, causing pain and increasing functional disability over time. Knowledge of the natural history of the three types of CHD facilitates choosing the most appropriate time for THR.

The transtrochanteric approach is essential in cases with low and high dislocation and in certain dysplastic hips with great limitation of the range of motion.

Restoration of the normal centre of rotation is fundamental for the joint biomechanics and the survival of the prosthesis.

Shortening of the femur, if needed, is better to be performed at the level of the femoral neck.

In the majority of cases, special implants are needed to reconstruct the acetabulum and the femur.

The improvement of the QoL, especially in young females with high dislocation, is impressive. Most of these patients stated that after surgery they feel “like they were born gain”.

ACKNOWLEDGEMENTS

Authors would like to thank Dr. Konstantina Stathopoulou for her kind suggestions regarding the writing style of this work.

Footnotes

Manuscript source: Invited manuscript

Specialty type: Orthopedics

Country of origin: Greece

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