Observational Study Open Access
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Aug 18, 2024; 15(8): 744-753
Published online Aug 18, 2024. doi: 10.5312/wjo.v15.i8.744
Anterior cruciate ligament reconstruction: Effect of graft tunnel position on early to mid-term clinical outcomes
Oliver Mann, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
Oday Al-Dadah, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
Oday Al-Dadah, Department of Trauma and Orthopaedic Surgery, South Tyneside District Hospital, Harton Lane, South Tyneside NE34 0PL, United Kingdom
ORCID number: Oliver Mann (0000-0002-8317-9864); Oday Al-Dadah (0000-0002-1940-836X).
Author contributions: Mann O contributed to conceptualization, investigation, writing-original draft, writing-review and editing, and visualization; Al-Dadah O contributed to conceptualization, methodology, validation, formal analysis, resources, writing-review and editing, supervision, and project administration.
Institutional review board statement: This was reviewed and approved by the Institution’s Clinical Effectiveness Department at South Tyneside District Hospital (Approval No. CA10358).
Informed consent statement: All patients included in this study signed informed consent forms to have their data included (anonymously) for the purpose of research. It forms part of their standard of care treatment consent forms. Due to our hospitals Data Protection policy, we cannot send out all the patients signed consent forms to a third party.
Conflict-of-interest statement: We confirm that all authors have no conflicts of interest.
Data sharing statement: Not applicable.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Oliver Mann, Master’s Student, Research Fellow, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom. oliver.mann1@nhs.net
Received: January 18, 2024
Revised: May 30, 2024
Accepted: July 9, 2024
Published online: August 18, 2024
Processing time: 207 Days and 15.6 Hours

Abstract
BACKGROUND

Patient reported outcome measures (PROMs) can be used to assess knee function following anterior cruciate ligament (ACL) reconstruction. Intra-operatively, femoral and tibial tunnels are created to accommodate the new ACL graft. It is postulated that there is an optimum position and orientation of these tunnels and that outcomes from this procedure are affected by their position.

AIM

To evaluate the influence of graft tunnel position on early to mid-term clinical outcomes following ACL reconstruction.

METHODS

Six PROMs were collected following ACL reconstruction which included the Knee Injury and Osteoarthritis Outcome Score (KOOS), International Knee Documentation Committee, Lysholm, Tegner, EuroQol-5 Dimension-5 level, and Short Form 12-item Health Survey. A total of 8 radiological parameters were measured from post-operative X-rays relating to graft tunnel positions. This data was analysed to assess for any correlations between graft tunnel position and post-operative PROMs.

RESULTS

A total of 87 patients were included in the study with a mean post-operative follow-up of 2.3 years (range 1 to 7 years). Posterior position of tibial tunnel was associated with improved KOOS quality of life (rho = 0.43, P = 0.002) and EQ-5D VAS (rho = 0.36, P = 0.010). Anterior position of EndoButton femoral tunnel was associated with an improved EQ-5D index (rho = -0.38, P = 0.028). There were no other significant correlations between any of the other radiological parameters and PROM scores.

CONCLUSION

Overall, graft tunnel position had very little correlation with clinical outcomes following ACL reconstruction. A few (posterior) tibial tunnel and (anterior) EndoButton femoral tunnel measurements were associated with better PROMs.

Key Words: Anterior cruciate ligament, Reconstruction, Patient reported outcome measures, Graft tunnel, X-ray, Correlation

Core Tip: This is an observational cross-sectional study investigating the effect of graft tunnel position following anterior cruciate ligament reconstruction and its association with patient reported outcome measures (PROMs). PROMs were collected before and at a minimum of 12 months following surgery. The results of these questionnaires were analysed to determine whether radiological measurements of graft tunnel position had a significant impact on early to mid-term clinical outcomes. If significance is found, it is important to determine the most optimal position for the tunnels to improve patients’ function following these procedures.



INTRODUCTION

Anterior cruciate ligament (ACL) rupture is a debilitating injury for an increasing number of patients. It is estimated that between 100000 and 200000 cases of ACL rupture occur in the United States every year[1]. Consequently, the volume of ACL reconstruction surgery being performed is rising. Between 1994 and 2006 the frequency of ACL reconstruction surgery has risen by 37% in the United States[2]. The procedure requires a new graft to be fixed in place of the original ACL in order to restore knee stability. As a requirement for the graft to be fixed in place, bone tunnels must be drilled into the tibia and femur to accommodate the new graft. These tunnels must be drilled in a position that allows the new graft to have the same orientation as the native ACL, and thereby improve the functional stability of the knee joint[3-5]. It is postulated that the position and orientation of these tunnels have an effect on post-operative clinical outcomes for patients. Current national guidelines in the United Kingdom state that the femoral tunnel should be placed in an anatomical or near-anatomical position, between 9 o’clock and 11 o’clock (right knee) or between 1 o’clock and 3 o’clock (left knee) as referenced from clock face positions in the coronal plane[6]. If the position of the femoral tunnel is too anterior in the sagittal plane, there is risk of loss of full flexion of the knee and graft rupture once movement is regained following surgery[6]. If the tunnel is too posterior in the sagittal plane, there is a risk of it breaking through the posterior wall of the femur[6]. The tibial tunnel is generally placed in the middle third of the tibia, too anterior and it can lead to loss of extension due to impingement, too posterior it can impinge on the posterior cruciate ligament (PCL)[6].

Patient reported outcome measures (PROMs) are used to generate quantitative data relating to the clinical function of the knee joint. Patients complete validated questionnaires which can be used to quantify the level of disability associated with an ACL rupture and the functional improvement following surgery. They can also be used to evaluate various patient and surgical factors associated with functional outcome which can better inform clinical practice.

The aim of this study was to evaluate the influence of graft tunnel position on early to mid-term clinical outcomes following ACL reconstruction. The hypothesis is that no correlation exists between radiological parameters and post-operative PROMs.

MATERIALS AND METHODS

This is an observational cross-sectional study. All the patients included in this study attended a specialist knee clinic and underwent ACL reconstruction surgery following clinical assessment and radiological investigation between October 2015 and April 2022. This study was registered with the Institution’s Clinical Effectiveness Department (registration number CA10358). This therapeutic research study constituted part the first author’s Masters dissertation. Some of the post-operative PROM data points presented in this study were also used in another longitudinal observational study which has also been submitted for publication, but all the radiological data points and the analysis itself in this study are entirely original.

Inclusion criteria consisted of patients with an ACL rupture whose symptoms where refractory to an initial period of conservative treatment (i.e., physiotherapy, activity modification, etc.) who subsequently underwent an arthroscopic primary, anatomic single bundle ACL reconstruction using either middle third bone-patella tendon-bone autograft or quadrupled hamstring tendon (gracilis and semitendinosus) autograft. Hamstring grafts were secured to the femur via suspensory fixation using EndoButton (Smith & Nephew Inc., Andover, MA, United States) and to the tibia using radiolucent polyetheretherketone (PEEK) interference screws (Smith & Nephew Inc., Andover, MA, United States) or round cannulated interference screws (Smith & Nephew Inc., Andover, MA, United States). Patella tendon grafts were secured using Softsilk interference screws (Smith & Nephew Inc., Andover, MA, United States) both in the femur and the tibia. The femoral tunnel was drilled using the transportal technique for both graft types and the tibial tunnel was drilled using a standard tibial jig set to 60 degrees for the patella tendon graft and 55 degrees for the hamstring graft. Both the femoral and tibial tunnels were centred on the native ACL footprint. Exclusion criteria consisted of PCL tear, multi-ligament reconstruction, revision ACL reconstruction and advanced osteoarthritis.

PROMs

A total of 6 validated PROMs were used in this study which included the Knee Injury and Osteoarthritis Outcome Score (KOOS)[7,8], EuroQol-5 Dimension-5 level (EQ-5D-5L)[9-12], International Knee Documentation Committee (IKDC) score[13,14], Tegner score[15], Lysholm score[15], and the 12-item Short Form survey[16]. There were two patients who were under 16 years of age at the time of surgery but were aged over 16 years at the latest point of contact post-operatively at the time of conducting this study (via postal questionnaire) and therefore completed the same (adult) PROM forms as the rest of the study cohort.

Radiological assessment

Post-operative X-rays were evaluated by the first author, after receiving appropriate training from the senior author and thereafter a proforma was devised and adhered to. Accuracy was ensured by initially repeating the evaluation on a patient sample to allow for recognition of errors in calculation and/or measurements on X-rays. The interobserver reliability of these measurements has previously been evaluated by Nema et al[17] and found to have high intraclass correlation coefficients (ranging from 0.71 to 0.96) between reviewers. The following radiological measurements were evaluated as illustrated in Figure 1.

Figure 1
Figure 1 Radiological parameters on X-ray imaging. A: Coronal angle of the tibial tunnel (α); B: Coronal angle of the femoral tunnel (β); C: Coronal position of the tibial tunnel AB/AC (%); D: Transplant orientation to joint angle (μ); E: Sagittal position of the tibial tunnel DE/DF (%); F: Position along Blumensaat’s line GH/GI (%); G: EndoButton position (anterior, middle, or posterior); H: Femoral tunnel angle to femoral diaphysis (º).

Coronal angle of the tibial tunnel (α) (Figure 1A)[17]. This angle is found by drawing a line over the tibial plateau on an AP radiograph, intersected by a line following the course of the tibial tunnel. The angle is measured between these two lines and gives the coronal angle of the tibial tunnel[17].

Coronal angle of the femoral tunnel (β) (Figure 1B)[17]. This angle is found by drawing a line across the lowermost points of the femoral condyles on an AP radiograph, intersected by a line following the course of the femoral tunnel. The angle is measured between these two lines and gives the coronal angle of the femoral tunnel[17].

Coronal position of the tibial tunnel ab/ac (%) (Figure 1C)[17]. This is found by drawing a line across the tibial plateau on an AP radiograph, and this line is measured. A line is drawn that intersects the tibial plateau line, that runs through the centre of the tibial tunnel. The distance between the medial-most point of the tibial plateau and the point where these two lines intersect is measured and expressed as a percentage distance of the width of the tibial plateau[17].

Transplant orientation to joint angle (μ) (Figure 1D)[18]. The angle is found by drawing a line parallel to the tibial plateau on a lateral radiograph. A second line is drawn parallel to the direction of the tibial tunnel. The angle where these two lines intersect is the transplant orientation to joint angle[18].

Sagittal position of the tibial tunnel de/df (%) (Figure 1E)[17]. A line is drawn across the tibial plateau on lateral radiograph and measured. Another line is drawn through the centre of the tibial tunnel. The distance from the most anterior point of the tibial plateau to where these two lines intersect is measured and expressed as a percentage length of the tibial plateau line. This is the sagittal tibial tunnel position[17].

Position along Blumensaat’s line gh/gi (%) (Figure 1F)[17,19]. This was measured only for patients who had an interference screw in the femoral tunnel. First, the position along Blumensaat’s line was measured. Blumensaat’s line is drawn on a lateral radiograph along the roof of the intercondylar notch of the femur and measured[19]. Another line is drawn through the centre of the femoral tunnel. The distance from where these two lines intersect and the most posterior point of Blumensaat’s line is measured and expressed as a percentage of the length of Blumensaat’s line. This is the femoral tunnel position along Blumensaat’s line[17].

EndoButton position (anterior, middle, or posterior) (Figure 1G)[20]. To find this, two lines are drawn parallel to the anterior and posterior cortices of the femur on lateral radiograph. Two further lines are drawn between these two lines in a way that the three spaces between these four lines are all the same width. From this point, it can be assessed whether the EndoButton is anterior, middle, or posterior[20].

Femoral tunnel angle to femoral diaphysis (º) (Figure 1H)[21]. This is found by drawing a line parallel to the femoral diaphysis from the intercondylar notch on AP radiograph. Another line is drawn from the intercondylar notch, through the centre of the EndoButton. The angle between these lines is measured and recorded as the angle of femoral tunnel to femur[21].

Statistical analysis

Plotted histograms with fitted curve lines, box-plots, normal Q-Q plots, and the Shapiro-Wilk statistic were used to test normality of data distribution. All the radiological measurement data (continuous variables) and all the PROM data (continuous variables) displayed a skewed distribution and therefore the relevant non-parametric statistical tests were used for the data analysis. The Spearman’s Rank correlation test was used for the main correlation analysis and the Kruskal-Wallis H test was used for the comparison between EndoButton positions. The level of statistical significance was set at P < 0.05. Statistical analysis was performed using SPSS for Windows version 28.0 (IBM Corp., Armonk, NY, United States).

RESULTS

Table 1 shows the demographics of the patients in the study at the time of surgery, showing a mean age of 31.5, over twice as many males as females (60:27) (more males participated in at risk activities which result in ACL rupture), and a mean body mass index of 27.5.

Table 1 Patient demographics.
Item
n = 87
Age (years), mean (range)31.5 (12.0-62.0)
Sex (male:female)60:27
Laterality (left:right)44:43
Graft type (hamstring:BTB)60:27
Height (cm), mean ± SD174.3 ± 8.8
Weight (kg), mean ± SD84.1 ± 18.0
BMI (kg/m2), mean ± SD27.5 ± 5.4

Table 2 shows the measurements of the post-operative X-ray parameters as described in Figure 1. Table 3 shows the results of all the post-operative PROM data collected. The mean time between surgery and completion of post-operative PROM questionnaires was 2.3 years (range 1.0 to 7.0 years).

Table 2 Post-operative radiological parameters.
Item
Median (inter-quartile range)
Coronal position tibial tunnel (%)46.3 (42.7-49.6)
Coronal angle tibial tunnel (º)70.8 (66.7-76.4)
Coronal angle femoral tunnel (º)45.7 (39.8-52.0)
Sagittal position tibial tunnel (%)44.8 (38.4-54.5)
Transplant orientation to joint (º)68.3 (60.7-72.7)
Position along Blumensaat’s line (%)47.2 (36.3-53.8)
Angle of femoral tunnel to femur (º)38.9 (35.2-43.7)
Table 3 Post-operative patient reported outcome measures data.
Item
Median (inter-quartile range)
KOOS pain89 (78-97)
KOOS symptom79 (68-86)
KOOS ADL97 (90-100)
KOOS sport/rec75 (60-85)
KOOS QoL63 (44-75)
KOOS overall81 (70-87)
IKDC75 (64-86)
Lysholm87 (76-91)
Tegner5 (4-7)
EQ-5D index0.837 (0.728-1.000)
EQ-5D VAS85 (70-90)
SF-12 MCS53 (45-58)
SF-12 PCS54 (47-57)

Figure 2 shows the numbers of patients in each position for EndoButton placement. The middle position was the most common for EndoButton placement which is in keeping with the anatomic ACL footprint targeted as part of the surgical technique. Table 4 shows that none of the PROM scores showed a significant difference dependent on the position of the EndoButton after ACL reconstruction using hamstring tendon autograft.

Figure 2
Figure 2 EndoButton position.
Table 4 Comparison of post-operative patient reported outcome measures with EndoButton position.

Anterior, median (IQR)
Middle, median (IQR)
Posterior, median (IQR)
P value1
H
KOOS pain88 (73-97)85 (67-95)88 (82-91)0.7480.6
KOOS symptom79 (68-89)79 (57-83)83 (68-88)0.6121.0
KOOS ADL98 (87-100)92 (71-97)95 (92-96)0.2273.0
KOOS sport/rec78 (61-85)73 (45-75)73 (51-75)0.3931.9
KOOS QoL57 (25-80)56 (31-65)57 (40-69)0.8200.4
KOOS overall81 (64-85)77 (59-82)79 (67-83)0.4401.6
IKDC75 (53-77)69 (56-77)71 (64-72)0.6640.8
Lysholm88 (71-94)85 (74-89)83 (74-89)0.7220.7
Tegner5 (3-7)5 (3-7)4 (2-5)0.4541.6
EQ-5D index1 (0.746-1.000)0.750 (0.657-0.919)0.704 (0.668-0.810)0.0974.7
EQ-5D VAS74 (61-84)88 (64-91)73 (70-86)0.1613.6
SF-12 MCS51 (47-59)54 (40-59)54 (37-58)0.9640.1
SF-12 PCS55 (50-57)52 (35-56)46 (44-47)0.2662.7

Table 5 shows that overall, there was no significant correlation between PROM scores and radiological parameters. The sagittal position of the tibial tunnel showed significant positive correlations with KOOS quality of life sub-score (P = 0.002), and the EQ-5D VAS sub-score (P = 0.010). Better scores were achieved in patients who had tibial tunnels placed more posteriorly. There was also a significant negative correlation between EndoButton position and the EQ-5D index sub-score (P = 0.028). Patients scored better if they have a more anterior EndoButton position.

Table 5 Correlation between post-operative patient reported outcome measures and radiological parameters1.


Coronal position TT
Coronal angle TT
Coronal angle FT
Sagittal position TT
TOJ
Position along Blumensaat’s line
Angle of FT to femur
EndoButton position
KOOS painrho0.150-0.1600.0400.2000.0300.3700.090-0.090
P value0.2970.2510.8010.1580.8090.1090.6030.621
KOOS symptomrho0.030-0.150-0.0300.210-0.050-0.0500.060-0.050
P value0.8280.2850.8180.1270.7090.8230.7360.778
KOOS ADLrho0.093-0.1400.1900.200-0.0600.140-0.150-0.240
P value0.5070.3170.1780.1500.6880.5480.4100.170
KOOS sport/recrho0.110-0.0400.2000.1200.0100.3200.030-0.220
P value0.4360.7710.1660.4100.9440.1900.8640.220
KOOS QoLrho0.230-0.1100.2000.430-0.2000.0800.010-0.020
P value0.0970.4410.1470.002a0.1570.7350.9560.928
KOOS overallrho0.170-0.0400.1600.250-0.0900.2300.020-0.140
P value0.2200.7570.2550.0800.5510.3440.9190.423
IKDCrho0.180-0.1000.1500.2600.0700.2600.170-0.160
P value0.2020.5170.2880.0600.6350.2680.3580.381
Lysholmrho0.010-0.210-0.1100.200-0.0200.2900.290-0.140
P value0.9210.1390.4460.1660.8980.2320.1050.453
Tegnerrho-0.0400.200-0.0200.2000.1400.1300.130-0.180
P value0.7660.1780.9130.9000.3330.5820.5000.355
EQ-5D indexrho0.060-0.150-0.0100.260-0.1000.3100.070-0.380
P value0.6590.2850.9330.0680.4910.1920.6980.028a
EQ-5D VASrho0.0300.020-0.0800.360-0.1800.0100.1300.240
P value0.8200.8910.5660.010a0.2130.9620.4610.174
SF-12 MCSrho0.000-0.140-0.0700.110-0.0100.1100.0400.050
P value0.9990.3390.6500.4590.9560.6410.8220.797
SF-12 PCSrho0.170-0.1100.1200.220-0.1000.290-0.070-0.280
P value0.2440.4670.4050.1440.5240.2230.7320.129
DISCUSSION

This study has shown that overall, graft tunnel position does not correlate with post-operative clinical outcomes following ACL reconstruction.

Although there were no significant differences between median post-operative PROM scores with EndoButton position, there was a significant correlation between anterior EndoButton position and improved EQ-5D index sub-score. Conversely, Kazemi et al[22] found that improved clinical outcomes were associated with a more posteriorly placed EndoButton. Post-operative X-rays demonstrated that the EndoButton was most frequently positioned in the middle of the femur which is consistent with the anatomic surgical technique which targeted the centre of the ACL footprint. The post-operative PROM results showed no significant differences between the three EndoButton positions (anterior, middle, and posterior). This implies that EndoButton position has minimal effect on clinical outcomes, a finding supported by Gunaydin et al[20].

Graft tunnel position was not shown to effect PROMs to a significant extent, but the sagittal position of the tibial tunnel showed significant correlations with two of the outcome measures, higher scores being associated with a more posteriorly placed tibial tunnel. The more posterior the tibial tunnel, the greater scores were reported in KOOS quality of life and EQ-5D VAS sub-scores. However, Pinczewski et al[23] found that a more posteriorly placed tibial tunnel had greater association with re-rupture, and a more vertical inclination of the tibial tunnel was associated with persistent rotational instability following surgery[23]. Other studies evaluating graft tunnel position also suggested that a more posteriorly placed tibial tunnel was associated with worse outcomes and a greater degree of rotational instability[24,25]. One study looked at the effect of graft tunnel position on clinical outcomes, using IKDC, and graft failure rates[26]. They found that position of the tunnels had no effect on IKDC scores, a finding supported in the present study[26]. However, they concluded that a more anteriorly placed femoral tunnel was associated with an increased graft failure rate. This is an outcome that was not evaluated in the present study due to the very small number of re-ruptures. Larger studies would be required to investigate this association further. Kazemi et al[22] also found a correlation between a smaller coronal angle of the femoral tunnel (less vertical, more horizontal) and improved clinical outcomes, which was not found in the present study.

Opinion is varied when discussing optimal positioning of drilled tunnels for single bundle ACL reconstruction[27], however there are some well-established pitfalls within the literature. A tibial tunnel that is too anterior increases the risk of intercondylar notch roof impingement, which can lead to a higher rate of graft failure[28]. Roof impingement can present clinically as loss of full extension and an increase in laxity post-operatively[28]. The risk of roof impingement is potentially reduced if the tunnels are drilled within the original footprints of the native ACL[28]. The present study showed significantly improved PROMs for patients with a more posteriorly placed tibial tunnel, supporting this theory.

Another type of impingement that can occur is impingement on the PCL. This is most likely to occur whilst in flexion when the new graft lies on top of the PCL[28]. Again, drilling the tunnels within the footprints of the native ACL has the potential to reduce this risk, along with drilling the femoral tunnel at a 60º angle in the coronal plane[28,29]. On the other hand, one study found that depending on femoral footprint position, certain individuals may be over 50 times as likely to suffer from an ACL rupture[30]. They found that people that had suffered from an ACL rupture had significantly different femoral footprints than those who did not, those with a more posterior footprint and one that is more proximal to the flexion-extension axis of the knee are at greater risk[30]. This could lead to the formulation of the question, if people who rupture their ACL have an abnormal femoral footprint that predisposes them to ACL rupture, why is anatomical reconstruction seen as the most optimal reconstruction method for these patients?

When discussing the femoral tunnel, the clock face method is the most often referenced. The United Kingdom national guidelines state that optimal positioning for the femoral tunnel is between 9 o’clock and 11 o’clock (right knee) or between 1 o’clock and 3 o’clock (left knee)[6]. However, there are many different descriptions of the clock face method that exist and using different methods causes significant variations in tunnel position[31,32]. For this reason, a number of authors have recommended against using this method[31,32].

Allografts, although not routinely recommended for primary ACL reconstruction in younger, active patients, are often indicated for revision ACL reconstructions[33]. The tunnel placements recommended for allograft tissue are the same as for autograft tissue, described as “anatomical positioning”[33]. This requires the tunnels accommodating the new graft to be within the native ACL “footprint”, to achieve similar position and orientation as the native ACL[24]. However, Borque et al[24] also state that anatomical positioning alone is not optimal for any ACL reconstruction, as the footprint of the native ACL is often larger than the new graft size. As a result, it is recommended that the tibial tunnel aperture is drilled in the most anterior position of the native footprint, without causing graft impingement in the notch[24]. As for the femoral tunnel, the isometric anteromedial position of the tunnel aperture within the native footprint is recommended[24].

Despite finding an association that is opposite to previous studies[23-25], a particular strength of the present study was the wide variety of PROM instruments that were used. Previous studies have either only used IKDC[23,26] or Lysholm scores in isolation[22]. The main limitation of this study was the additional number of patients that were lost to follow-up as otherwise a greater total number of patients could have been included in this study. This was a pragmatic clinical study of real time clinical practice and as such is subject to the variables which effect every day clinical practice. Patients who undergo ACL reconstruction are generally young patients who often move away from the hospital from which they had their original surgery for work purposes (i.e., university students graduating and moving to another city, etc.). All the radiological parameters were measured by one reviewer only (the first author) which may present a potential limitation of this study. However, to mitigate this factor, sufficient training was delivered by the senior author and a proforma was devised and adhered to throughout the data collection process. Intra- and inter-observer reliability was not the focus of this study as this has already been evaluated by other published studies[17] and could also inform suggestions for future researchers[17].

CONCLUSION

Overall, graft tunnel position, as evaluated by radiological parameters from post-operative X-rays, had very little correlation with clinical outcomes following ACL reconstruction. A few tibial tunnel measurements (posteriorly placed) and EndoButton femoral tunnel measurement (anteriorly placed) were associated with better PROM scores.

Footnotes

Provenance and peer review: Invited article; Externally peer reviewed.

Peer-review model: Single blind

Specialty type: Orthopedics

Country of origin: United Kingdom

Peer-review report’s classification

Scientific Quality: Grade C

Novelty: Grade A

Creativity or Innovation: Grade A

Scientific Significance: Grade A

P-Reviewer: Casado A S-Editor: Chen YL L-Editor: A P-Editor: Zheng XM

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