Regulation of bone destruction in rheumatoid arthritis through RANKL-RANK pathways

Figure 1 Inflammatory synovial proliferation and bone erosion (arrows) by osteoclasts in rheumatoid arthritis patients.

Figure 2 Immunostaining of synovial fibroblasts obtained from osteoarthritis (A) and rheumatoid arthritis (B) patients with anti-receptor activator of nuclear factor κB ligand antibody.

Figure 3 Plain X ray (A), computed tomography scan (B and C) and magnetic resonance imaging (D) of the right hand of an autosomal dominant II patient with rheumatoid arthritis. Erosion of the carpal bones (B) and severe synovitis, as determined by the high intensity areas by T2-weighted magnetic resonance imaging images (D), were observed[14].