Single- and double-dose of platelet-rich plasma versus hyaluronic acid for treatment of knee osteoarthritis: A randomized controlled trial

Figure 1 CONSORT flowchart.

Figure 2 Comparison of the pain score indices between the three intervention groups at baseline and subsequent follow-ups. A: Comparison of the percentage change in pain from baseline to wk 4 (1^st follow-up), wk 8 (2^nd follow-up) and wk 12 (3^rd follow-up) between the three groups; B: Comparison of the mean pain scores at baseline and subsequent follow-ups between the three groups. Negative shows a benefit from pre-treatment values.

Figure 3 Comparison of the stiffness score indices between the three intervention groups at baseline and subsequent follow-ups. A: Comparison of the percentage change in stiffness from baseline to wk 4 (1^st follow-up), wk 8 (2^nd follow-up), and wk 12 (3^rd follow-up) between the three groups; B: Comparison of the mean stiffness scores at baseline and subsequent follow-ups between the three groups. Negative shows a benefit from pre-treatment values.

Figure 4 Comparison of the physical function score indices between the three intervention groups at baseline and subsequent follow-ups. A: Comparison of the percentage change in physical function from baseline to wk 4 (1^st follow-up), wk 8 (2^nd follow-up), and wk 12 (3^rd follow-up) between the three groups; B: Comparison of the mean physical function scores at baseline and subsequent follow-ups between the three groups. Negative shows a benefit from pre-treatment values.

Figure 5 Comparison of the total Western Ontario and McMaster Universities Arthritis Index scores between the three intervention groups at baseline and subsequent follow-ups. A: Comparison of the percentage change in total scores from baseline to wk 4 (1^st follow-up), wk 8 (2^nd follow-up), and wk 12 (3^rd follow-up) between the three groups; B: Comparison of the mean total scores at baseline and subsequent follow-ups between the three groups. Negative shows a benefit from pre-treatment values.

Figure 6 Comparison of the Visual Analogue Scale pain scores between the three intervention groups at baseline and subsequent follow-ups. A: Comparison of the percentage change in scores from baseline to wk 4 (1^st follow-up), wk 8 (2^nd follow-up), and wk 12 (3^rd follow-up) between the three groups; B: Comparison of the mean scores at baseline and subsequent follow-ups between the three groups. Negative shows a benefit from pre-treatment values.