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©The Author(s) 2018.
World J Clin Oncol. Nov 10, 2018; 9(7): 123-132
Published online Nov 10, 2018. doi: 10.5306/wjco.v9.i7.123
Published online Nov 10, 2018. doi: 10.5306/wjco.v9.i7.123
Table 1 Demographic characteristics for the breast cancer and benign pathology groups
Breast cancer (n = 48) | Benign pathology (n = 26) | P value1 | |
Mean age (yr) | 57.79 ± 14.13 (range: 31-85) | 32.54 ± 11.63 (range: 14-60) | 0.000 |
Menarche (yr) | 12.42 ± 1.67 (range: 9-16) | 12.62 ± 1.69 (range: 9-17) | 0.763 |
Term pregnancy | 2.63 ± 2.27 (range: 0-11) | 1.50 ± 1.55 (range: 0-5) | 0.066 |
Sexual partners | 1.98 ± 1.15 (range: 0-5) | 1.76 ± 1.09 (range: 1-3) | 0.750 |
Oral contraceptives | 47.92% | 65.38% | 0.352 |
Tobacco | 50.00% | 11.53% | 0.002 |
Alcohol | 47.92% | 46.15% | 0.678 |
Breast cancer family history | 37.50% | 19.23% | 0.199 |
Table 2 Mean absolute values for the cellular subsets in the breast cancer and benign pathology groups
Breast cancer (cel/mm3) | Benign pathology (cel/mm3) | P value1 | |
TCD3+ | 1517.95 ± 666.23 | 1861.68 ± 760.52 | 0.102 |
TCD4+ | 888.73 ± 445.18 | 974.01 ± 390.17 | 0.504 |
TCD8+ | 551.34 ± 284.35 | 764.54 ± 431.10 | 0.048 |
CD4+/CD8+ | 1.94 (range: 0.59-6.33) | 1.57 (range: 0.64-4.36) | 0.271 |
Table 3 Correlations between the breast cancer molecular subtypes and the cellular subtypes
CD4+ (cel/mm3) | CD8+ (cel/mm3) | NK+ (cel/mm3) | |
Luminal A | 916 ± 358.81 | 645 ± 299.91 | 1064 ± 455.61 |
Luminal B HER2- | 877 ± 494.16 | 544 ± 273.04 | 1120 ± 818.37 |
Luminal B HER2+ | 914 ± 318.73 | 491 ± 208.07 | 926 ± 500.35 |
HER2+ | 680 ± 444.86 | 426 ± 319.13 | 834 ± 836.75 |
TN | 992 ± 568.02 | 483 ± 214.90 | 1183 ± 837.52 |
P value1 | 0.842 | 0.527 | 0.912 |
Table 4 Correlations between the breast cancer HPV status and the cellular subtypes
HPV+ (n = 14) | HPV- (n = 34) | P value1 | |
CD3+ (cel/mm3) | 1832.12 ± 537.08 | 1399.56 ± 665.69 | 0.563 |
CD4+ (cel/mm3) | 1139.92 ± 416.84 | 796.56 ± 416.84 | 0.091 |
CD8+ (cel/mm3) | 630.66 ± 271.00 | 518.58 ± 281.53 | 0.748 |
CD4+/CD8+ | 2.11 (range: 0.71-4.17) | 1.88 (range: 0.59-6.33) | 0.029 |
NK+ (cel/mm3) | 1350.21 ± 736.79 | 950.47 ± 634.35 | 0.082 |
- Citation: Fernandes A, Pesci-Feltri A, García-Fleury I, López M, Guida V, De Macedo M, Correnti M. Lymphocyte subsets predictive value and possible involvement of human papilloma virus infection on breast cancer molecular subtypes. World J Clin Oncol 2018; 9(7): 123-132
- URL: https://www.wjgnet.com/2218-4333/full/v9/i7/123.htm
- DOI: https://dx.doi.org/10.5306/wjco.v9.i7.123