Study of recombinant human interleukin-12 for treatment of complications after radiotherapy for tumor patients

Table 1 Results of whole blood test for the treatment group and the control group (mean ± SD, n = 10)

Group	Indicator	0 d	12 h	3 d	7 d	14 d	21 d	28 d
Control	WBC (× 109/L)	7.66 ± 0.82	5.5 ± 0.67	4.2 ± 0.39	4.3 ± 0.48	4.21 ± 0.62	4.69 ± 0.38	4.89 ± 0.63
	RBC (× 1012/L)	3.92 ± 0.31	4.26 ± 0.43	3.9 ± 0.41	3.93 ± 0.22	4.38 ± 0.36	3.86 ± 0.34	3.89 ± 0.28
	PLT (× 109/L)	358 ± 0.43	339 ± 31.45	232 ± 20.43	258 ± 19.2	275 ± 0.31	296 ± 0.29	321 ± 0.26
50 ng/kg	WBC (× 109/L)	6.31 ± 0.59	3.6 ± 0.35	4.27 ± 0.46	4.85 ± 0.35	4.52 ± 0.42	4.72 ± 0.39	5.18 ± 0.52
	RBC (× 1012/L)	5.43 ± 0.54	4.92 ± 0.53	4.16 ± 0.38	4.59 ± 0.82	4.73 ± 0.32	5.26 ± 0.37	5.63 ± 0.41
	PLT (× 109/L)	231 ± 20.81	185 ± 18.24	195 ± 18.97	205 ± 18	226 ± 18.2	246 ± 17.5	229 ± 19.4
100 ng/kg	WBC	8.4 ± 0.45	7.7 ± 7.89	5.3 ± 10.64	6.6 ± 0.98	6.1 ± 0.64	5.73 ± 0.47	5.9 ± 0.21
	RBC (× 1012/L)	6.3 ± 0.72	3.37 ± 0.43	3.2 ± 0.34	4.2 ± 0.37	4.78 ± 0.46	4.5 ± 0.42	4.6 ± 0.34
	PLT (× 109/L)	231 ± 27.2	185 ± 10.7	178 ± 12.6	195 ± 12.8	166 ± 10.9	182 ± 12.5	205 ± 15.3
150 ng/kg	WBC (× 109/L)	6.6 ± 0.73	5.4 ± 0.76	3.8 ± 0.35	5.2 ± 0.37	5.7 ± 0.42	6.2 ± 0.54	6.3 ± 0.54
	RBC (× 1012/L)	3.4 ± 0.36	3.5 ± 0.37	3.2 ± 0.29	3.3 ± 0.28	3.6 ± 0.24	3.6 ± 0.26	3.44 ± 0.21
	PLT (× 109/L)	367 ± 35.75	352 ± 32.45	306 ± 30.12	316 ± 16	357 ± 17	348 ± 26	317 ± 16
200 ng/kg	WBC (× 109/L)	5.3 ± 0.8	4.2 ± 0.3	3.2 ± 0.1	3.5 ± 0.32	3.6 ± 0.27	4.3 ± 0.31	5.4 ± 0.43
	RBC (× 1012/L)	4.6 ± 0.51	4.2 ± 0.41	4.1 ± 0.45	4.2 ± 0.3	4 ± 0.2	4.12 ± 0.34	4.5 ± 0.42
	PLT (× 109/L)	278 ± 36	183 ± 19	149 ± 14	208 ± 22	259 ± 24	267 ± 25	271 ± 21
250 ng/kg	WBC (× 109/L)	3.6 ±	3 ± 0.37	2.7 ± 0.24	3.4 ± 0.4	4.2 ± 0.3	4.5 ± 0.4	4.2 ± 0.4
	RBC (× 1012/L)	3.6 ± 0.3	3.3 ± 0.2	3.1 ± 0.2	3.2 ± 0.3	3.4 ± 0.3	3.7 ± 0.2	4.1 ± 0.3
	PLT (× 109/L)	364 ± 35	235 ± 21	240 ± 20	276 ± 22	314 ± 19	342 ± 21	312 ± 20

WBC: White blood cell; RBC: Red blood cell; PLT: Platelet.

Table 2 Results of immunologic detection for the treatment group and the control group (mean ± SD, n = 10)

Group	Indicator	0 d	12 h	3 d	7 d	14 d	21 d	28 d
Control	CD4/8	20.4 ± 2.6	18 ± 1.2	17.5 ± 1.2	17.8 ± 1.3	18.4 ± 1.2	17.3 ± 1.4	16.5 ± 0.4
	CD45	75.2 ± 7.5	68.1 ± 5.2	65.4 ± 4.2	83.3 ± 5.2	79.3 ± 3.7	62.4 ± 5.1	60.3 ± 3.6
	CD56	12.3 ± 1.2	8.7 ± 0.6	7.6 ± 0.5	11.4 ± 1.3	10.4 ± 0.9	8.2 ± 0.6	6.7 ± 0.5
50 ng/kg	CD4/8	28.2 ± 1.8	22.4 ± 1.6	19.8 ± 1.6	19.6 ± 1.6	21.4 ± 1.8	18.8 ± 1.2	16.9 ± 1.4
	CD45	81.9 ± 2.4	78.8 ± 5.1	75.2 ± 3.6	82.9 ± 3.8	79.8 ± 5.6	62.4 ± 4.6	51.8 ± 4.3
	CD56	27.9 ± 2.2	21.9 ± 1.8	19.2 ± 1.2	22.1 ± 1.8	19.7 ± 2.1	21.6 ± 1.3	22.4 ± 0.9
100 ng/kg	CD4/8	15.4 ± 1.5	12.7 ± 1.2	11.5 ± 1.1	10.6 ± 1.2	10.1 ± 0.3	9.2 ± 0.4	8.7 ± 0.2
	CD45	84.3 ± 2.6	66.1 ± 3.8	68.7 ± 3.5	67.9 ± 4.4	57.6 ± 4.6	63.1 ± 3.6	70.2 ± 3.1
	CD56	14.8 ± 1.8	8.9 ± 0.6	10.8 ± 0.9	12.3 ± 1.5	10.4 ± 4.6	12.9 ± 0.3	11.6 ± 0.4
150 ng/kg	CD4/8	16.5 ± 1.2	12.8 ± 1.2	11.6 ± 0.9	13.1 ± 4.6	12.6 ± 1.5	10.8 ± 0.9	7.6 ± 0.5
	CD45	74.2 ± 3.6	63.2 ± 3.2	66.1 ± 4.8	82.7 ± 5.2	68.1 ± 4.6	75.2 ± 4.2	65.1 ± 4.1
	CD56	6.2 ± 0.3	6.5 ± 0.3	5.9 ± 0.3	7.9 ± 0.6	8.2 ± 7.4	8.8 ± 0.9	6.5 ± 0.1
200 ng/kg	CD4/8	9.6 ± 0.4	8.3 ± 0.61	7.6 ± 0.6	7.2 ± 0.9	8.6 ± 4.6	8.2 ± 1.2	6.1 ± 0.2
	CD45	64.5 ± 4.2	60.7 ± 4.2	65.8 ± 4.4	76.6 ± 5.9	74.3 ± 4.6	73.2 ± 5.2	55.9 ± 5.0
	CD56	3.8 ± 0.2	2.8 ± 0.2	4.4 ± 0.4	4.9 ± 0.9	6.2 ± 0.6	5.9 ± 0.3	4.5 ± 0.1
250 ng/kg	CD4/8	6.4 ± 0.2	5.7 ± 0.2	4.2 ± 0.3	4.7 ± 0.3	3.5 ± 0.3	3.4 ± 0.9	3.1 ± 0.9
	CD45	46.5 ± 3.9	40.2 ± 3.2	57.9 ± 4.1	66.5 ± 3.8	54.9 ± 4.2	50.4 ± 4.9	35.9 ± 3.2
	CD56	4.3 ± 0.2	3.9 ± 0.2	5.4 ± 0.4	6.3 ± 0.5	6.6 ± 0.3	7.2 ± 0.6	6.4 ± 0.8

Table 3 Results of objective evaluation for the treatment group and the control group

Group	n	CR	%	PR	%	MR	%	PD	%
Treatment	50	12	24a	30	60	5a	10a	3a	6a
Control	10	5	10	25	50	10	20	10	20

Compared with the control group,

^aP < 0.05. CR: Complete remission; PR: Partial remission.

Table 4 Comparison of ECOG scores before and 1 mo after intervention for the treatment and control groups

ECOG scores before treatment after treatment
Treatment group (n = 50)
0	0	11a
1	10	15a
2	15	19a
3	20	5a
4	5	0a
Control group (n = 50)
0	1	4
1	11	16
2	17	20
3	15	10
4	6	0

There was significant difference between the two groups,

^aP < 0.05.