Tann AW, Hatch SS, Joyner MM, Wiederhold LR, Swanson TA. Accelerated partial breast irradiation: Past, present, and future. World J Clin Oncol 2016; 7(5): 370-379 [PMID: 27777879 DOI: 10.5306/wjco.v7.i5.370]
Corresponding Author of This Article
Todd A Swanson, MD, PhD, Department of Radiation Oncology, the University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0711, United States. taswanso@utmb.edu
Research Domain of This Article
Oncology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
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Invasive ductal or other favorable subtypes (mucinous, tubular, and colloid)
pN0; by SLN or axillary dissection
Table 4 Phase III prospective randomized trials evaluating the equivalence or non-inferiority of accelerated partial breast irradiation with whole-breast irradiation
Age ≥ 50 yr; T ≤ 3 cm, node negative; invasive adenocarcinoma; margin ≥ 2 mm
IMRT; Arm 1: 40 Gy in 15 fractions to primary tumor region + 36 Gy in 15 fractions to low-risk region (EBRT) Arm 2: 40 Gy in 15 fractions to primary tumor region (EBRT)
Pending
IRMA (NCT01803958)
3302 (Currently Enrolling)
Pending
Age ≥ 49 yr; T < 3 cm, N0; invasive carcinoma; margins ≥ 2 mm
38.5 Gy in 10 fractions using 3D-CRT, BID
Pending
SHARE (NCT01247233)
1006
Pending
Age ≥ 50 yr; invasive carcinoma; T ≤ 2 cm; margin≥ 2 mm; pN0 (i+/-)
3D-CRT 40 Gy in 10 fractions, BID
Pending
NSABP B-39/RTOG 0413
4300
Pending
Age ≥ 18 yr; DCIS or invasive adenocarcinoma; stage 0, I, II (T < 3 cm); lumpectomy; margins free of tumor; ≤ 3 positive nodes
34 Gy in 10 fractions using MIB or MammoSite®/MammoSite® ML/SAVI® or 38.5 Gy over 10 fractions using 3D-CRT
Pending
Citation: Tann AW, Hatch SS, Joyner MM, Wiederhold LR, Swanson TA. Accelerated partial breast irradiation: Past, present, and future. World J Clin Oncol 2016; 7(5): 370-379