Acetylcholine receptor pathway in lung cancer: New twists to an old story

Table 1 Qualified genome-wide association studies at the 15q25.1 region on the risk of lung cancer

Date	PubMedID	Ref.	Initialsample size	Replicationsample size	Chromosomeposition	Mappedgene	SNP	Context	P value	OR (95%CI)	Platform
8/4/2009	19654303	Broderick et al[9]	1952 European ancestry cases, 1438 European ancestry controls	5608 European ancestry cases, 6767 European ancestry controls	78806023	AGPHD 1	rs8034191	intron	3.00E-26	1.29 (1.23-1.35)	Illumina
11/2/2008	18978790	McKay et al[6]	2971 cases, 3746 controls	2899 cases, 5573 controls	78894339	CHRNA 3	rs1051730	cds- synon	1.00E-15	1.35 (1.25-1.45)	Illumina
11/2/2008	18978787	Wang et al[8]	1952 cases, 1438 controls	7579 cases, 8236 controls	78908032	CHRNA 3	rs8042374	intron	8.00E-12	NR	Illumina
9/17/2008	18780872	Liu et al[10]	194 cases, 219 controls	3878 cases, 4831 controls	78806023	AGPHD 1	rs8034191	intron	1.00E-8	1.38 (1.17-1.64)	Affymetrix
4/3/2008	18385676	Amos et al[2]	1154 cases, 1137 controls	2724 cases, 3694 controls	78806023	AGPHD 1	rs8034191	intron	3.00E-18	1.30 (1.15-1.47)	Illumina
4/3/2008	18385738	Hung et al[3]	1926 cases, 2522 controls	2513 cases, 4752 controls	78806023	AGPHD 1	rs8034191	intron	5.00E-20	1.30 (1.23-1.37)	Illumina
10/15/ 2009	19836008	Landi et al[11]	5739 European descent cases, 5848 European descent controls	7561 European descent cases, 13818 European descent controls	78894339	CHRNA 3	rs1051730	cds- synon	2.00E-51	1.31 (1.27-1.36)	Illumina