Current aspects of therapeutic reduction mammaplasty for immediate early breast cancer management: An update

Table 1 Oncological and outcome using reduction mammaplasty techniques

Ref.	Year	Technique	n	Tumor size (cm)	Follow-up (mo)	Local recurrence (%)	Patient satisfaction (%)
Papp et al[12]	1998	Superior pedicle	10	NR	52	5	95
Nos et al[71]	1998	Superior pedicle	50	3.25	48	7	85
Spear et al[18]	2003	Superior pedicle	56	NR	46	6.9	91
Clough et al[41]	2003	Superior pedicle	101	3.2	24	0	88
Chang et al[19]	2004	Superior pedicle	37	0.6-5.2	NR	0	NR
Goffman et al[74]	2005	Superior pedicle	57	NR	18	13	82
Munhoz et al[15]	2006	Superior pedicle	74	2-4.0	22	0	93
Munhoz et al[16]	2006	Superior-medial pedicle	39	2-4.0	20	0	90
Munhoz et al[17]	2007	Inferior pedicle	26	2-4.0	21	0	89
Fitoussi et al[47]	2010	Superior pedicle	540	2.9	49	6.8	90

Table 2 Oncological and outcome evidence for delivery of adjuvant chemotherapy after immediate breast-conservation surgery reconstruction

Ref.	Year	n	Tumor size (cm)	Adjuvant chemotherapy n (%)	Delay in chemotherapy	Delayed adjuvant chemotherapy n (%)
Nos et al[71]	1998	50	Tis-T4	5 (10)	+	3 (6)
Losken et al[23]	2002	20	Tis-N/D	N/D	-	0
Clough et al[41]	2003	101	T1-T4	0	+	4 (4)
Spear et al[18]	2003	22	N/D	22 (100)	-	0
McCulley et al[53]	2005	50	Tis-N/D	23 (46)	-	0
Munhoz et al[15]	2006	74	T1-T2	22 (29.7)	-	0
Thornton et al[54]	2006	6	T1-T2	0	-	0
Kronowitz et al[50]	2007	41	Tis-T2	18 (44)	-	0
Losken et al[25]	2007	63	Tis-N/D	N/D	-	0
Rietjens et al[42]	2007	148	T1-T3	89 (60)	-	0
Meretoja et al[72]	2010	90	Tis-T3	60 (67)	+	2 (2)
Fitoussi et al[47]	2010	540	T1-T3	N/D	+	10 (1.9)
Song et al[55]	2010	28	Tis	N/A	-	0
Romics et al[56]	2012	31	T1-T3	31 (100)	-	0
Kahn et al[28]	2013	169	T1-T3	N/D	-	0

N/D: Not disclosed; N/A: Not applicable; (+): Positive; (-): Negative.

Table 3 Immediate breast-conservation surgery reconstruction and therapeutic reduction mammaplasty techniques: surgical margins and outcome

Ref.	n	Follow-up (mo)	Tumor size (cm)	Positive margins (%)	Local recurrence (%)
Clough et al[41] 2003	101	46	3.2 (0.1-7)	10.9	6.9
Clough et al[7] 1999	20	54	NS	0	5
Nos et al[71] 1998	50	48	3.5 (1.5-6)	10	7
Papp et al[12] 1998	10	52	NS	0	5
Masetti et al[75] 2000	56	23	NS	NS	0
Spear et al[18] 2003	11	24	NS	0	0
Chang et al[19] 2004	37	NS	0.6-5.2	2.7	0
Losken et al[23] 2002	14	23	1.5 (0.6-3)	28.6	0
Munhoz et al[15] 2006	74	22	1.9 (0.6-3.9)	9.5	0
Fitoussi et al[47] 2010	540	49	2.9	5	6.8

NS: Not specified.