Incidental diagnosis of gallbladder carcinoma during or after routine cholecystectomy: A retrospective study with emphasis on clinicopathologic findings

Table 1 Incidental diagnoses determined via pathological examination of gallbladder specimens from patients who had cholecystectomy for benign gallbladder disease, n (%)

Incidental diagnosis	n = 29678
Malignant
Adenocarcinoma	42 (0.14)
Adenocarcinoma in situ	1 (0.003)
Benign
Accessory/ectopic liver lobe	9 (0.03)
Paraganglioma	3 (0.01)

Table 2 Demographic characteristics and preoperative diagnoses of patients with incidental gallbladder adenocarcinoma determined by pathological analysis of cholecystectomy specimens

Characteristic	Result (n = 42)
Age, years, mean ± SD	71 ± 13
Age, years, range	36-91
Sex, n (%)
Female	30 (71)
Male	12 (29)
Female-to-male ratio	2.3
Preoperative diagnosis, n (%)
Acute cholecystitis	20 (48)
Chronic cholecystitis	13 (31)
Cholelithiasis	7 (17)
Benign gallbladder polyp	2 (5)

Table 3 Clinicopathological descriptions of gallbladder specimens and metastatic outcomes for patients with incidental gallbladder adenocarcinoma, n (%)

Item	n = 42
Macroscopic characteristics
Associated with gallstones	34 (81)
Thickened wall	7 (17)
Growth or polyp	10 (24)
AJCC Staging
T1	5 (12)
T2	20 (48)
T3	16 (38)
Not recorded	1 (2)
Adenocarcinoma differentiation
Well-differentiated	7 (17)
Moderately differentiated	18 (43)
Poorly differentiated	17 (40)
Signet ring cell morphology	3 (7.1)
Peritoneal metastasis	1 (2.4)
Lymph node involvement	3 (7.1)

AJCC: American Joint Committee on Cancer.