Helicobacter pylori infection promotes the progression of gastric cancer by regulating the expression of DMBT1

doi:10.5306/wjco.v16.i5.105322

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May 24, 2025 (publication date) through May 19, 2025

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. May 24, 2025; 16(5): 105322
Published online May 24, 2025. doi: 10.5306/wjco.v16.i5.105322

Table 1 Comparison of relative expression of deleted in malignant brain tumors 1 mRNA in each group

Group	mean ± SD	vs group	95%CI	F	η²
Control	1.03 ± 0.04^b^,^c^,^d	H. pylori	0.20-0.41	185.10	0.986
		si-DMBT1	0.41-0.63
		H. pylori + si-DMBT1	0.64-0.86
H. pylori	0.73 ± 0.04^a^,^c^,^d	si-DMBT1	0.11-0.32
		H. pylori + si-DMBT1	0.34-0.55
si-DMBT1	0.52 ± 0.02^a^,^b^,^d	H. pylori + si-DMBT1	0.12-0.34
H. pylori + si-DMBT1	0.29 ± 0.05^a^,^b^,^c

^aP < 0.05 vs control group.

^bP < 0.05 vs Helicobacter pylori group.

^cP < 0.05 vs si-DMBT1 group.

^dP < 0.05 vs Helicobacter pylori + si-DMBT1 group.

H. pylori: Helicobacter pylori; DMBT1: Deleted in malignant brain tumors 1; CI: Confidence interval.

Table 2 Comparison of relative expression of deleted in malignant brain tumors 1 protein in each group

Group	mean ± SD	vs group	95%CI	F	η²
Control	0.57 ± 0.08^b^,^c^,^d	H. pylori	0.13-0.35	82.57	0.967
		si-DMBT1	0.30-0.53
		H. pylori + si-DMBT1	0.40-0.62
H. pylori	0.33 ± 0.02^a^,^c^,^d	si-DMBT1	0.06-0.29
		H. pylori + si-DMBT1	0.16-0.38
si-DMBT1	0.16 ± 0.03^a^,^b	H. pylori + si-DMBT1	0.02-0.21
H. pylori + si-DMBT1	0.06 ± 0.02^a^,^b

^aP < 0.05 vs control group.

^bP < 0.05 vs Helicobacter pylori group.

^cP < 0.05 vs si-DMBT1 group.

^dP < 0.05 vs Helicobacter pylori + si-DMBT1 group.

H. pylori: Helicobacter pylori; DMBT1: Deleted in malignant brain tumors 1; CI: Confidence interval.

Table 3 Comparison of relative proliferative capacities in each group

Group	mean ± SD	vs group	95%CI	F	η²
Control	0.68 ± 0.05^b^,^c^,^d	H. pylori	-0.20 to -0.09	47.84	0.878
		si-DMBT1	-0.25 to -0.14
		H. pylori + si-DMBT1	-0.38 to -0.27
H. pylori	0.82 ± 0.06^a^,^d	si-DMBT1	-0.11 to 0.01
		H. pylori + si-DMBT1	-0.24 to -0.12
si-DMBT1	0.87 ± 0.04^a^,^d	H. pylori + si-DMBT1	-0.19 to -0.07
H. pylori + si-DMBT1	1.00 ± 0.03^a^,^b^,^c

^aP < 0.05 vs control group.

^bP < 0.05 vs Helicobacter pylori group.

^cP < 0.05 vs si-DMBT1 group.

^dP < 0.05 vs Helicobacter pylori + si-DMBT1 group.

H. pylori: Helicobacter pylori; DMBT1: Deleted in malignant brain tumors 1; CI: Confidence interval.

Table 4 Comparison of relative migratory capacities in each group

Group	mean ± SD	vs group	95%CI	F	η²
Control	0.09 ± 0.009^b^,^c^,^d	H. pylori	-0.21 to -0.10	151.40	0.974
		si-DMBT1	-0.36 to -0.25
		H. pylori + si-DMBT1	-0.55 to -0.44
H. pylori	0.24 ± 0.05^a^,^c^,^d	si-DMBT1	-0.20 to -0.10
		H. pylori + si-DMBT1	-0.39 to -0.28
si-DMBT1	0.39 ± 0.03^a^,^b^,^d	H. pylori + si-DMBT1	-0.24 to -0.13
H. pylori + si-DMBT1	0.58 ± 0.04^a^,^b^,^c		-0.21 to -0.10

^aP < 0.05 vs control group.

^bP < 0.05 vs Helicobacter pylori group.

^cP < 0.05 vs si-DMBT1 group.

^dP < 0.05 vs Helicobacter pylori + si-DMBT1 group.

H. pylori: Helicobacter pylori; DMBT1: Deleted in malignant brain tumors 1; CI: Confidence interval.

Table 5 Comparison of relative invasive capacities in each group

Group	mean ± SD	vs group	95%CI	F	η²
Control	39.20 ± 4.00^b^,^c^,^d	H. pylori	-49.44 to -34.16	514.75	0.990
		si-DMBT1	-90.04 to -74.76
		H. pylori + si-DMBT1	-143.04 to -127.76
H. pylori	81.00 ± 3.54^a^,^c^,^d	si-DMBT1	-48.24 to -32.96
		H. pylori + si-DMBT1	-101.24 to -85.96
si-DMBT1	121.60 ± 5.23^a^,^b^,^d	H. pylori + si-DMBT1	-60.64 to -45.36
H. pylori + si-DMBT1	174.60 ± 8.62^a^,^b^,^c

^aP < 0.05 vs control group.

^bP < 0.05 vs Helicobacter pylori group.

^cP < 0.05 vs si-DMBT1 group.

^dP < 0.05 vs Helicobacter pylori + si-DMBT1 group.

H. pylori: Helicobacter pylori; DMBT1: Deleted in malignant brain tumors 1; CI: Confidence interval.

Citation: Zhou X, Wang LQ, Song S, Xu M, Li CP. Helicobacter pylori infection promotes the progression of gastric cancer by regulating the expression of DMBT1. World J Clin Oncol 2025; 16(5): 105322
URL: https://www.wjgnet.com/2218-4333/full/v16/i5/105322.htm
DOI: https://dx.doi.org/10.5306/wjco.v16.i5.105322