Combined BRAF G469A mutation and echinoderm microtubule associated protein like-4-anaplastic lymphoma kinase rearrangement with resistance: A case report and review of literature

Table 1 Characteristics of blood in clinic

	Nov 2020	Dec 2020	Jan 2021	Feb 2021	Mar 2021	Apr 2021	May 2021	Jun 2021	Jul 2021	Aug 2021	Sep 2021	Oct 2021	Nov 2021	Dec 2021	Jan 2022	Feb 2022	Mar 2022	Apr 2022
WBC (109/L)	6.7	7.3	4.4	3.7	6.8	7.2	6.1	5.8	5.3	5.4	6.4	8.2	9	19.2	4.7	5.9	4.1	3
Hb (g/L)	138	127	120	115	117	115	108	112	117	106	98	113	95	102	89	95	97	87
Plt (109/L)	253	267	223	213	242	223	267	252	265	252	301	296	432	392	423	456	349	297
ALT (IU/L)	30.4	54.3	103.8	25.3	35.2	19.6	26.1	19.7	21.4	27.9	14.3	15.1	13.1	16.6	187.9	12.1	19.8	17.1
AST (IU/L)	33.2	43.2	61.9	57.8	27.3	32.9	28.2	33.3	32.9	41.1	23.7	23.2	18.9	20.3	153.7	25.2	25.7	24.5
CEA (U/mL)	58.8	16.4	3.7	4.6	5.2	4.2	3.8	1	2.1	1.5	1.7	1.4	65.8	3.1	3.3	2	7.2	3.95
CA125 (ng/mL)	9.3	3.5	4.2	15.6	6.9	7.2	5.4	5.1	9.6	23.9	46.6	35	495.5	104.6	35.1	14.7	1.6	2.74

WBC: White blood cell; Hb: Hemoglobin; Plt: Platelet; ALT: Alanine transaminase; AST: Aspartate transaminase; CEA: Carcinoembryonic antigen; CA125: Carbohydrate antigen 125.