Preparation of kakkatin derivatives and their anti-tumor activity

Table 1 IC₅₀ value of kakkatin and 6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one on tumor Cells (μM)

Drug	SMMC-7721 cells	MGC803 cells
Cisplatin	17.54	20.83
Kakkatin	76.93	38.24
The 6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one	2.50	39.51

Table 2 The docking energy of 6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one and genes

Complex	Gene	Affinity (kcal/mol)
7bvq-molecule1-1	ADRB1	-9.6
1so2-molecule1-1	PDE3B	-9.5
P22694-molecule1-1	PRKACB	-7.4
7 Lfc-molecule1-1	NFKB1	-5.9