Receptor tyrosine kinase-like orphan receptor 1: A novel antitumor target in gastrointestinal cancers

Table 1 Receptor tyrosine kinase-like orphan receptor 1-targetd therapies in clinical trials or preclinical studies

Therapy types	Therapy drugs	Indications	ClinicalTrials.gov Identifier/Ref.
mAb	Zilovertamab	Gastric cancer Pancreatic cancer	[42]
ADC	VLS-101	Solid tumor	NCT04504916
	LCB71		NCT05279300
	NBE-002		NCT04441099
	miR-29b		[47]
	OSU-2S		[48]
Bispecific antibody	R11×v9-BiAb	Solid tumor	[50]
	NVG-111		NCT04763083
	SFG.ROR1-BiTE	Pancreatic cancer	[51]
Small-molecule inhibitors	KAN0439834	Pancreatic cancer	[54]
	KAN04415711C		[55]
	miR-27b-3p	Gastric cancer	[57]

mAb: Monoclonal antibodies; ADC: Antibody drug conjugate.