Clinical and Translational Research
Copyright ©The Author(s) 2024.
World J Clin Oncol. Feb 24, 2024; 15(2): 208-242
Published online Feb 24, 2024. doi: 10.5306/wjco.v15.i2.208
Table 1 List of core mRNAs of ATP-induced cell death
Gene
Full name
Role in ATP induced cell death
Ref.
P2RX7Purinergic receptor P2X7Activate inflammatory mediators and increase calcium ionsTamajusuku et al[22]
CASP3Caspase-3Caspase-3 cleavage by caspase-1/4/5/11 forms pores, releasing pro-inflammatory cytokinesSouza et al[1]
PANX1Pannexin-1P2X7 activation opens PANX1 channels, releasing ATP and triggering cell death pathwaysShoji et al[36]
NLRP3NOD-like receptor family pyrin domain-containing protein 3NLRP3 activated by stimuli forms inflammasome, triggers caspase-1 activation, releases cytokines, and induces apoptosisSadatomi et al[37]
CASP1Caspase-1Caspase-1 induces cytokine processing, pyrosis, and inflammationSadatomi et al[37]
P2RY1P2Y purinoceptor 1P2RY1 can increase calcium ions in the Golgi apparatusOhishi et al[38]
P2RY11P2Y purinoceptor 11Involved in immune inflammatory mechanismsYoon et al[39]
ORAI1Calcium release-activated calcium channel protein 1 Increased intracellular calcium ionsPeng et al[26]
STIM1Stromal interaction molecule 1STIM1 responds to ATP-induced calcium influx, activating ORAI1 and promoting cell deathPeng et al[26]
CASP8Caspase-8CASP8 causes apoptosisZhao et al[40]
CASP9Caspase-9CASP9 causes apoptosisZhao et al[40]
CASP7Caspase-7CASP7 causes apoptosisZhao et al[40]
P2RX3Purinergic receptor P2X3NAOhishi et al[38]
NLRP1NLR family pyrin domain-containing protein 1NLRP1 activates caspase-1, induces pyrodeath, and releases IL-1β and IL-18Zhao et al[41]
P2RX4P2X purinoceptor 4P2RX4 contributes to AICD (pyroptosis) by activating the NLRP3 inflammasome, leading to IL-1β and IL-18 productionOhishi et al[38]
P2RX5P2X purinoceptor 5NAOhishi et al[38]
SAPKStress-activated protein KinaseATP induces cell death via SAPK pathways, regulating apoptosis, necrosis, and stress signalingHumphreys et al[42]
p38 MAPKp38 mitogen-activated protein kinases (p38 MAPK)ATP activates p38 MAPK, which leads to cell death through apoptosis and necrosisNoguchi et al[2]
ASK1Apoptosis signal-regulating kinase 1.Excessive ATP induces cellular stress, activating ASK1 and downstream pathways for cell deathNoguchi et al[2]
NOX2NADPH oxidase 2ATP activates NOX2, generating ROS causing oxidative stress and potential cell deathNoguchi et al[2]
baxBCL-2-associated XExcessive ATP triggers BAX activation, mitochondrial dysfunction, and apoptotic cell deathWen et al[43]
MLCMyosin Light ChainATP depletion hampers muscle contraction, affecting myosin function and cellular viabilityHwang et al[44]
ROCK IRho-associated, coiled-coil containing protein kinase 1ATP activates P2X7 receptors, inducing apoptosis via the Rho/ROCK pathway, potentially involving ROCK IHwang et al[44]
ERK1/2Extracellular signal-regulated kinase 1 and 2ERK1/2 promotes cell survival or antagonizes apoptosis, but prolonged activation may lead to cell death. Activates the ERK1/2 pathway, affecting cell fateTsukimoto et al[45]
P2RX6P2X purinoceptor 6Activation may raise calcium levels, potentially triggering cell death[46]
CYTCCytochrome cCytochrome c released by mitochondria during cell stress triggers cell apoptosisSadatomi et al[37]
TNF-αTumor necrosis factor alphaATP induces cell death, activating TNF-α and triggering apoptosis or necroptosis pathways. Immune cells produce TNF-α in response to ATP, amplifying the cellular responseHide et al[47]
P2RY5P2R purinoceptor 5NAYoon et al[39]
P2RY14P2R purinoceptor14NAOhishi et al[38]
P2RY13P2R purinoceptor 13P2Y13 may play a role in ADP receptors, involved in ATP homeostasisOhishi et al[38]
P2RY12P2R purinoceptor 12P2Y12 may play a role in ADP receptors, involved in ATP homeostasisOhishi et al[38]
P2RY6P2R purinoceptor 6P2Y6 may be involved in calcium signaling leading to cell deathYoon et al[39]
P2RY4P2R purinoceptor 4P2Y6 may be involved in calcium signaling leading to cell deathOhishi et al[38]
P2RY2P2R purinoceptor 2ATP binding triggers intracellular signaling pathways that may lead to cell deathOhishi et al[38]
ANO6Anoctamin-6As a calcium-activating channel and superburning enzyme, it may influence cell death pathwaysOusingsawat et al[48]
cyclinE2Cyclin E2NAWang et al[49]
cyclinD2Cyclin D2NAWang et al[49]
Table 2 MicroRNAs corresponding to the mRNA of a prognostic model
Number
Species
miRNA
Genes
MIRT134791Homo sapienshsa-miR-765CCND2
MIRT064764Homo sapienshsa-miR-665CCND2
MIRT040184Homo sapienshsa-miR-615-3pCCND2
MIRT064762Homo sapienshsa-miR-610CCND2
MIRT732948Homo sapienshsa-miR-574-3pCcnd2
MIRT535518Homo sapienshsa-miR-548nPANX1
MIRT535500Homo sapienshsa-miR-548d-5pPANX1
MIRT064724Homo sapienshsa-miR-520c-3pCCND2
MIRT064723Homo sapienshsa-miR-520bCCND2
MIRT064719Homo sapienshsa-miR-519c-3pCCND2
MIRT064722Homo sapienshsa-miR-519b-3pCCND2
MIRT042101Homo sapienshsa-miR-484CASP7
MIRT337453Homo sapienshsa-miR-4306CCND2
MIRT038097Homo sapienshsa-miR-423-5pCCND2
MIRT043702Homo sapienshsa-miR-342-3pCCND2
MIRT042861Homo sapienshsa-miR-324-3pCCND2
MIRT044790Homo sapienshsa-miR-320aCCND2
MIRT113093Homo sapienshsa-miR-3163CCND2
MIRT064741Homo sapienshsa-miR-3125CCND2
MIRT007217Homo sapienshsa-miR-206CCND2
MIRT021301Homo sapienshsa-miR-125a-5pPANX1