Comprehensive assessment of the association between tumor-infiltrating immune cells and the prognosis of renal cell carcinoma

Table 1 Clinical characteristics of patients

Variables	Clinical characters	Numbers
Age in years	≤ 65	343
	> 65	181
Sex	Female	185
	Male	339
T stage	T1	269
	T2	66
	T3	178
	T4	11
M stage	M0	418
	M1	78
	MX	28
N stage	N0	236
	N1	15
	N2	273
Stage	Stage I	263
	Stage II	54
	Stage III	124
	Stage IV	83
Grade	G1	14
	G2	227
	G3	206
	G4	77

The 305 cases of kidney cancer patients lack clinical data.

Table 2 Results of univariate cox regression analysis for 22 immune cells in renal cell carcinoma

Immune cells	HR	HR 95L	HR 95H	P value
B cells naive	23260.95811	7.327755285	73838733.88	< 0.001
B cells memory	367.0654108	1.02E-14	1.32528E+19	0.761
Plasma cells	7.884077616	0.471946257	131.7071149	0.151
T cells CD8+	2.305757787	0.842062146	6.313689546	0.104
T cells CD4+ memory resting	0.350135006	0.061633114	1.989101538	0.236
T cells CD4+ memory activated	1100224.032	1157.449769	1045827605	< 0.001
T cells follicular helper	14026508.28	1930.466435	1.01915E+11	< 0.001
T cells regulatory	477.9895258	1.97885441	115457.704	0.028
T cells gamma delta	1.185772305	0.027650702	50.85064158	0.929
NK cells resting	14.09528528	0.052612618	3776.224703	0.354
NK cells activated	3.21804095	0.010005648	1034.994197	0.692
Monocytes	4.094791848	0.200859787	83.47773603	0.359
Macrophages M0	0.386593443	0.064142169	2.330050464	0.300
Macrophages M1	1864.763728	50.85250386	68380.97431	< 0.001
Macrophages M2	0.04122243	0.009170583	0.18529779	< 0.001
Dendritic cells resting	0.893700613	0.002682052	297.7946697	0.970
Dendritic cells activated	3.99E-09	2.39E-24	6648051.131	0.279
Mast cells resting	0.006154535	4.70E-05	0.806155892	0.051
Mast cells activated	2.46E-06	4.49E-18	1344373.927	0.349
Eosinophils	725332583.3	3.12E-14	1.69E+31	0.437
Neutrophils	18.26220316	0.311769833	1069.725255	0.162
T cells naive	\	\	\	\

HR 95L: Lower limit of the 95% confidence interval; HR 95H: Upper limit of the 95% confidence interval; NK: Natural killer; HR: Hazard ratio; M1: Normal activated subset; M2: Alternating-activated subset.

Table 3 Results of multivariate cox regression analysis for four immune cells in renal cell carcinoma patients

Immune cells	HR	HR 95L	HR 95H	P value
T cells CD4+ memory activated	72976.763	55.302	96300449.399	< 0.05
T cells follicular helper	3049.111	0.102	90834209.409	< 0.05
Macrophages M1	296.374	4.843	18138.002	< 0.05
Macrophages M2	0.230	0.036	1.452	< 0.05

HR 95L: Lower limit of the 95% confidence interval; HR 95H: Upper limit of the 95% confidence interval; HR: Hazard ratio; M1: Normal activated subset; M2: Alternating-activated subset.