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©The Author(s) 2022.
World J Clin Oncol. Jun 24, 2022; 13(6): 520-528
Published online Jun 24, 2022. doi: 10.5306/wjco.v13.i6.520
Published online Jun 24, 2022. doi: 10.5306/wjco.v13.i6.520
Table 1 Comparisons of patients’ characteristics according to the presence of lymph node metastasis of pancreatic neuroendocrine neoplasm
| Variables | Total (n = 82) | N- (n = 72) | N+ (n = 10) | P value | |
| Age, median (range) | 59 (18-81) | 58 (18-80) | 63 (18-81) | 0.65 | |
| Gender (male/female) | 41/41 | 35/37 | 6/4 | 0.50 | |
| Tumor size, median, mm (range) | 12 (5-90) | 12 (5-90) | 37 (12-75) | 0.0001 | |
| Tumor number (single/multiple) | 68/14 | 59/13 | 9/1 | 0.50 | |
| Tumor location (Ph/Pb/Pt/Ph and Pt) | 32/23/25/2 | 23/22/25/2 | 9/1/0/0 | 0.15 | |
| Symptoms (yes/no) | 35/47 | 31/41 | 4/6 | 0.85 | |
| CT Enhancement (hyper/hypo) | 72/10 | 64/8 | 8/2 | 0.17 | |
| Type of PNEN, n (%) | NS | ||||
| Insulinoma | 26 (32) | 26 | 0 | ||
| Gastrinoma | 2 (2.5) | 1 | 1 | ||
| Glucagonoma | 2 (2.5) | 2 | 0 | ||
| VIPoma | 1 (1) | 1 | 0 | ||
| Non functional | 51 (62) | 42 | 9 | ||
| WHO classification 2017, n (%) | 0.0009 | ||||
| NET G1 | 70 (85) | 66 | 4 (6%) | ||
| NET G2 | 9 (11) | 5 | 4 (44%) | ||
| NET G3/NEC | 3 (4) | 1 | 2 (67%) | ||
| Surgical procedure, n (%) | NS | ||||
| Pancreatoduodenectomy (PD) | 23 (28) | 15 | 8 | ||
| Distal pancreatectomy (DP) | 38 (46) | 37 | 1 | ||
| PD + DP | 2 (2.5) | 2 | 0 | ||
| Enucleation/partial pancreatectomy | 19 (23) | 18 | 1 | ||
Table 2 Factors related to lymph node metastasis of pancreatic neuroendocrine neoplasm
| Factors | Univariate analysis | Multivariate analysis | |||
| Odds ratio | P value | Odds ratio | 95%CI | P value | |
| Age ≥ 60 | 0.54 | 0.40 | |||
| Gender (male) | 0.63 | 0.50 | |||
| Symptoms (yes) | 1.13 | 0.85 | |||
| CT Enhancement (hyper) | 4 | 0.17 | |||
| Tumor number (multiple) | 1.98 | 0.50 | |||
| Tumor size (≥ 20 mm) | 31.5 | < 0.0001 | 16.8 | 2.15-35.4 | 0.0062 |
| WHO classification 2017 (≥ G2) | 20.1 | 0.0001 | NS | ||
| Type of PNEN (non functional) | 6.43 | 0.035 | NS | ||
- Citation: Nakao Y, Hayashi H, Yamashita YI, Takashi O, Matsumura K, Uemura N, Kitamura F, Itoyama R, Yusa T, Taki K, Miyata T, Higashi T, Nakagawa S, Okabe H, Imai K, Baba H. Risk factors for lymph node metastasis in patients with pancreatic neuroendocrine neoplasms. World J Clin Oncol 2022; 13(6): 520-528
- URL: https://www.wjgnet.com/2218-4333/full/v13/i6/520.htm
- DOI: https://dx.doi.org/10.5306/wjco.v13.i6.520