Review
Copyright ©The Author(s) 2021.
World J Clin Oncol. Jul 24, 2021; 12(7): 507-521
Published online Jul 24, 2021. doi: 10.5306/wjco.v12.i7.507
Table 1 Classification of proteoglycans with clinicopathological and/or functional significance in esophageal squamous cell carcinoma[14]
Location
Classification
Gene symbol
Eponym
Predominant GAG
Studied in ESCC
Ref.
IntracellularSecretory granulesSRGNSerglycinHeparin/CSSerglycinZhu et al[57]
Cell-surfaceTransmembraneSDCSyndecan 1-4HS/CSSyndecan-1, -2Mikami et al[58], Szumilo et al[60] and Huang et al[61]
CSPG4NG2CS/DS
TGFBR3BetaglycanHS/CS
PTPRZ1PhosphacanCS/DS
GPI-anchoredGPCGlypican 1-6HSGlypican-1, -3Hara et al[62], Li et al[63], Harada et al[64] and Song[65]
PericellularBasement membrane zoneHSPG2PerlecanHS/CS
AGRNAgrinHS
COL18A1Collagen XVIIIHSEndostatinZheng et al[71], Zhong et al[72] and Chen et al[73]
COL15A1Collagen XVCS/HS
ExtracellularHyalectansACANAggrecanCS/KS
VCANVersicanCS/DS
NCANNeurocanCS/DS
BCANBrevicanCS/DS
SLRPs, Canonical Class IDCNDecorinCS/DSDecorinWu et al[83], Ji et al[84] and Augoff et al[85]
BGNBiglycanCS/DSBiglycanZhu et al[97]
ASPNAsporin
ECM2ECM2
ECMXECMX
SLRPs, Canonical Class IIFMODFibromodulinKS
LUMLumicanKSLumicanKashyap et al[102,103]
PRELPPRELP
KERAKeratocanKS
OMDOsteoadherinKS
SLRPs, Canonical Class IIIEPYCEpiphycanCS/DS
OPTCOpticin
OGNOsteoglycin
SLRPs, Non-Canonical Class IVCHADChondroadherin
NYXNyctalopin
TSKUTsukushi
SLRPs, Non-Canonical Class VPODNPodocan
PODNL1Podocan-Like 1
SPOCKSPOCKTestican 1-3HSTestican-1Song et al[108]