Retrospective Study
Copyright ©The Author(s) 2020.
World J Clin Oncol. Apr 24, 2020; 11(4): 205-216
Published online Apr 24, 2020. doi: 10.5306/wjco.v11.i4.205
Table 1 Characteristics of patients who had curative resection of gastroenteropancreatic neuroendocrine tumours
Variablen (%)
GenderMale111 (51)
Female106 (49)
Age, yrMedian age59
ECOG PSPS 0140 (65)
PS 164 (30)
PS 28(3.7)
PS 35 (2.3)
LocalisationSmall bowel92 (42)
Pancreas55 (25)
Appendix39 (18)
Rectum15 (7)
Colon7 (3)
Stomach5 (2)
Other4 (2)
GradingGrade 1168 (77)
Grade 249 (23)
Surgical marginR0 resection186 (86)
R1 resection30 (13)
NA1 (0.5)
Vascular infiltrationPresent89 (41)
Absent109 (51)
NA19 (8)
Perineal infiltrationPresent64 (29)
Absent133 (62)
NA20 (9.3)
Tumour necrosisPresent10 (5)
Absent183 (86)
NA24 (10)
Lymph nodes retrieved≥ 8106 (49)
< 845 (21)
NA66 (31)
Lymph node involvementPositive114 (52)
Negative37 (17)
Serum CgA Level≥ ULN46(21)
Normal69 (32)
NA102 (47)
Serum 5-HIAA≥ ULN17 (8)
Negative96 (44)
NA104 (48)
Table 2 Univariate analysis of variables for relapse-free survival and overall survival in patients who had curative resection of gastroenteropancreatic neuroendocrine tumours
VariableLR P valueLR P value OS
Production of gut hormones0.0120.75
Production of CgA0.090.81
Production of 5 HIAA0.830.098
Genetic predisposition0.0110.71
Multiple NET0.590.25
Other active malignancy0.270.96
Vascular infiltration0.170.97
Perineural infiltration0.00230.016
Tumour necrosis0.660.021
≥ 8 lymph nodes retrieved0.0470.94
Any lymph nodes positive0.0330.78
Gender0.580.87
Localisation0.00490.44
T stage0.0150.22
N stage0.0080.58
M stage0.0890.17
Grade0.0391
Surgical margin0.320.69
ECOG performance status0.75< 0.0001
ACE comorbidity score0.390.044
Localisation0.630.61
Involved groups0.0620.09
TNM stage0.0190.19
Table 3 Multivariable analysis of variables associated with relapse-free survival in patients who had curative resection of gastroenteropancreatic neuroendocrine tumours
VariableHR95%CIP value
Presence of perineural infiltration: Yes1.570.81-3.060.1858
Over 8 lymph nodes retrieved: Yes2.651.06-6.620.0365
Any lymph nodes found positive: Yes2.620.88-7.780.0840
Localisation category: Pancreas (relative to “others”)10.691.95-58.560.0063
Localisation category: Small bowel (relative to “others”)12.172.19-67.690.0043