Copyright
©The Author(s) 2020.
World J Clin Oncol. Apr 24, 2020; 11(4): 205-216
Published online Apr 24, 2020. doi: 10.5306/wjco.v11.i4.205
Published online Apr 24, 2020. doi: 10.5306/wjco.v11.i4.205
Variable | n (%) | |
Gender | Male | 111 (51) |
Female | 106 (49) | |
Age, yr | Median age | 59 |
ECOG PS | PS 0 | 140 (65) |
PS 1 | 64 (30) | |
PS 2 | 8(3.7) | |
PS 3 | 5 (2.3) | |
Localisation | Small bowel | 92 (42) |
Pancreas | 55 (25) | |
Appendix | 39 (18) | |
Rectum | 15 (7) | |
Colon | 7 (3) | |
Stomach | 5 (2) | |
Other | 4 (2) | |
Grading | Grade 1 | 168 (77) |
Grade 2 | 49 (23) | |
Surgical margin | R0 resection | 186 (86) |
R1 resection | 30 (13) | |
NA | 1 (0.5) | |
Vascular infiltration | Present | 89 (41) |
Absent | 109 (51) | |
NA | 19 (8) | |
Perineal infiltration | Present | 64 (29) |
Absent | 133 (62) | |
NA | 20 (9.3) | |
Tumour necrosis | Present | 10 (5) |
Absent | 183 (86) | |
NA | 24 (10) | |
Lymph nodes retrieved | ≥ 8 | 106 (49) |
< 8 | 45 (21) | |
NA | 66 (31) | |
Lymph node involvement | Positive | 114 (52) |
Negative | 37 (17) | |
Serum CgA Level | ≥ ULN | 46(21) |
Normal | 69 (32) | |
NA | 102 (47) | |
Serum 5-HIAA | ≥ ULN | 17 (8) |
Negative | 96 (44) | |
NA | 104 (48) |
Variable | LR P value | LR P value OS |
Production of gut hormones | 0.012 | 0.75 |
Production of CgA | 0.09 | 0.81 |
Production of 5 HIAA | 0.83 | 0.098 |
Genetic predisposition | 0.011 | 0.71 |
Multiple NET | 0.59 | 0.25 |
Other active malignancy | 0.27 | 0.96 |
Vascular infiltration | 0.17 | 0.97 |
Perineural infiltration | 0.0023 | 0.016 |
Tumour necrosis | 0.66 | 0.021 |
≥ 8 lymph nodes retrieved | 0.047 | 0.94 |
Any lymph nodes positive | 0.033 | 0.78 |
Gender | 0.58 | 0.87 |
Localisation | 0.0049 | 0.44 |
T stage | 0.015 | 0.22 |
N stage | 0.008 | 0.58 |
M stage | 0.089 | 0.17 |
Grade | 0.039 | 1 |
Surgical margin | 0.32 | 0.69 |
ECOG performance status | 0.75 | < 0.0001 |
ACE comorbidity score | 0.39 | 0.044 |
Localisation | 0.63 | 0.61 |
Involved groups | 0.062 | 0.09 |
TNM stage | 0.019 | 0.19 |
Variable | HR | 95%CI | P value |
Presence of perineural infiltration: Yes | 1.57 | 0.81-3.06 | 0.1858 |
Over 8 lymph nodes retrieved: Yes | 2.65 | 1.06-6.62 | 0.0365 |
Any lymph nodes found positive: Yes | 2.62 | 0.88-7.78 | 0.0840 |
Localisation category: Pancreas (relative to “others”) | 10.69 | 1.95-58.56 | 0.0063 |
Localisation category: Small bowel (relative to “others”) | 12.17 | 2.19-67.69 | 0.0043 |
- Citation: Chiramel J, Almond R, Slagter A, Khan A, Wang X, Lim KHJ, Frizziero M, Chakrabarty B, Minicozzi A, Lamarca A, Mansoor W, Hubner RA, Valle JW, McNamara MG. Prognostic importance of lymph node yield after curative resection of gastroenteropancreatic neuroendocrine tumours. World J Clin Oncol 2020; 11(4): 205-216
- URL: https://www.wjgnet.com/2218-4333/full/v11/i4/205.htm
- DOI: https://dx.doi.org/10.5306/wjco.v11.i4.205