Practice change in the management of metastatic urothelial carcinoma after ASCO 2020

Table 1 Results of the most relevant studies at ASCO 2020

	JAVELIN Bladder 100[13]	FORT-2[16]	BLC2001[14]	COSMIC-021[18]	PEANUT[19]
Phase	3	1b/2	2	1b	2
Treatment	Avelumab + BSC vs BSC	Rogaratinib + atezolizumab	Erdafitinib	Cabozantinib + atezolizumab	Pembrolizumab + nab-paclitaxel
Inclusion criteria	Response or stable disease after 1st line platinum-based chemotherapy	Treatment naive	≥ 1 line or cisplatin unfit	≥ 1 line	1-2 lines
		Cisplatin ineligible	FGFR genetic alteration	Prior ICI not allowed	Prior ICI not allowed
		FGFR mRNA overexpression	Prior ICI allowed
Study population (n)	700	31	101	30	70
PFS (mo)	3.7 vs 2.0		5.52	5.4	5.0
OS (mo)	21.4 vs 14.3		11.3
ORR (%)	9.7 vs 1.4	44	40	27	38.6
Duration of response		NR	5.98	NR	NR

BSC: Best supportive care; ICI: Immune checkpoint inhibitor; FGFR: Fibroblast growth factor receptor; PFS: Progression-free survival; OS: Overall survival; ORR: Objective response rate.