Overall and cause-specific survival for mucoepidermoid carcinoma of the major salivary glands: Analysis of 2210 patients

doi:10.5306/wjco.v11.i12.1029

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World Journal of Clinical Oncology

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Dec 24, 2020; 11(12): 1029-1044
Published online Dec 24, 2020. doi: 10.5306/wjco.v11.i12.1029

Table 1 Overall survival analysis of mucoepidermoid carcinoma of the major salivary glands

	n	Median survival	Univariate hazard ratio		Multivariate hazard ratio
	n	95%CI	Estimate	95%CI	Estimate	95%CI
Age bands
00-09	11	Cannot estimate	Cannot estimate		Cannot estimate
10-19	86	Cannot estimate	0.12^a	0.02-0.37	0.13^c	0.06-0.32
20-29	174	Cannot estimate	0.16^a	0.07-0.32	0.18^c	0.12-0.26
30-39	275	Cannot estimate	0.62^b	0.42-0.92	0.73^c	0.68-0.78
40-49	319	401 ± 38.42	Reference		Reference
50-59	431	248 ± 13.93	2.55^a	1.93-3.39	2.51^c	2.33-2.69
60-69	381	167 ± 26.25	5.00^a	3.75-6.75	4.31^c	3.28-5.67
70-79	336	70 ± 17.94	11.38^a	8.25-15.95	7.52^c	6.91-8.18
80+	197	35 ± 6.87	20.02^a	13.67-29.92	12.24^c	11.58-12.95
Stage
Localized	1344	342 ± 26.24	Reference		Reference
Regional	591	99 ± 19.59	3.07^a	2.66-3.54	1.95^c	1.95-1.96
Distant	143	29 ± 9.64	6.96^a	5.51-8.75	2.84^c	2.73-2.95
Unknown	132	118 ± 61.69	2.69^a	1.86-3.80	1.6^b	1.11-2.31
Primary tumor size (mm)
0-10	209	Cannot estimate	Reference		Reference
11-20	576	331 ± 59.73	1.95^c	1.30-3.01	1.64^c	1.39-1.94
21-30	355	248 ± 54.66	3.15^a	2.08-4.91	2.07^c	1.36-3.13
31-40	150	141 ± 57.38	4.63^a	2.97-7.40	2.23^c	1.98-2.52
41-50	57	46 ± 38.76	9.26^a	5.56-15.59	2.66^c	1.52-2.81
> 50	87	52 ± 36.21	9.14^a	5.67-15.05	2.87^c	2.63-3.13
Unknown/unspecific	776	220 ± 26.3	3.43^a	2.35-5.18	2.09^c	1.73-2.51
Grade
I	403	401 ± 48.25	Reference		Reference
II	850	340 ± 33.68	1.26	0.98-1.63	1.30^b	1.02-1.67
III/IV	538	55 ± 11.05	5.44^a	4.27-6.99	2.10^c	1.98-2.23
Unknown	419	201 ± 39.44	2.49^a	1.94-3.20	1.61^c	1.52-1.70
Race
American Indian/Alaska Native	16	Cannot estimate	0.47	0.13-1.20	1.64	0.61-4.45
Asian or Pacific Islander	206	308 ± 66.3	0.70^b	0.53-0.91	0.93	0.71-1.21
Black	239	Cannot estimate	0.59^a	0.45-0.76	1.00	0.78-1.29
Unknown	23	Cannot estimate	0.10^c	0.00-0.54	0.31	0.04-2.26
White	1726	226 ± 21.22	Reference		Reference
Sex
Female	1093	327 ± 31.14	Reference		Reference
Male	1117	187 ± 22.69	1.76^a	1.54-2.01	1.26^b	1.10-1.44
Radiation
No/unknown	1200	340 ± 34.89	0.46^a	0.40-0.53	1.07	0.70-1.63
Yes	1010	147 ± 23.39	Reference		Reference
Sequence
Not applicable	1260	327 ± 29.07	Reference		Reference
Radiation after surgery	902	162 ± 25.62	1.82^a	1.59-2.08	1.18	0.76-1.83
Radiation before surgery	48	162 ± 56.48	1.67^b	1.12-2.40	1.17^c	1.10-1.25
Surgery
No	77	27 ± 11.81	4.26^a	3.16-5.64	2.09^c	1.40-3.10
Unknown	28	16 ± 10.37	4.43^a	2.87-6.57	2.41^c	1.43-4.05
Yes	2105	263 ± 23.24	Reference		Reference
Diagnosis year
1975-1995	960	221 ± 23.77	1.31^c	1.13-1.52	1.38^c	1.16-1.64
1996-2016	1250	Cannot estimate	Reference		Reference
Surgery type
Excision	2085	261 ± 23.23	Reference		Variable not used in multivariate analysis
Limited surgical procedure/biopsy	20	Cannot estimate	1.01	0.52-1.96
None	77	27 ± 11.81	4.28^a	3.17-5.67
Unknown	28	16 ± 10.37	4.44^a	2.88-6.59
Diagnosis year
1975-1984	405	207 ± 31.31	1.77^a	1.39-2.26	Variable not used in multivariate analysis
1985-1994	497	230 ± 36.99	1.50^c	1.18-1.91
1995-2004	564	Cannot estimate	1.32^b	1.04-1.68
2005-2016	744	Cannot estimate	Reference

^aP < 0.0001.

^bP < 0.05.

^cP < 0.001.

Table 2 Cause-specific survival analysis of mucoepidermoid carcinoma of the major salivary glands

	n	Median survival	Univariate hazard ratio		Multivariate hazard ratio
	n	95%CI	Estimate	95%CI	Estimate	95%CI
Age bands
00-09	11	Cannot estimate	Cannot estimate		Cannot estimate
10-19	86	Cannot estimate	0.23^b	0.03-0.90	0.28^b	0.10-0.74
20-29	174	Cannot estimate	0.23^b	0.06-0.67	0.29^c	0.16--0.51
30-39	275	Cannot estimate	0.71	0.37-1.34	0.95	0.85-1.06
40-49	319	Cannot estimate	Reference		Reference
50-59	431	Cannot estimate	2.50^a	1.62-3.96	1.99^c	1.30-3.06
60-69	381	Cannot estimate	3.34^a	2.17-5.29	2.47^c	2.18-2.80
70-79	336	Cannot estimate	5.41^a	3.48-8.67	3.00^c	2.63-3.43
80+	197	Cannot estimate	7.67^a	4.69-12.92	3.47^c	3.17-3.79
Stage
Localized	1344	Cannot estimate	Reference
Regional	591	Cannot estimate	7.46^a	5.78-9.70	3.90^c	3.77-4.04
Distant	143	41 ± 23.43	16.71^a	11.95-23.34	5.79^c	5.77-5.81
Unknown	132	Cannot estimate	6.27^a	3.62-10.38	3.01^c	1.79-5.05
Primary tumor size (mm)
0-10	209	Cannot estimate	Reference		Reference
11-20	576	Cannot estimate	1.87	0.86-4.62	1.4^b	1.01-1.92
21-30	355	Cannot estimate	5.08^a	2.41-12.34	2.13^c	1.48-3.06
31-40	150	Cannot estimate	8.18^a	3.75-20.31	2.27^b	1.04-4.95
41-50	57	Cannot estimate	17.24^a	7.48-44-63	3.19^c	2.44-4.17
> 50	87	89 ± 108.69	18.24^a	8.30-45.63	3.53^c	2.58-4.83
Unknown/unspecific	776	Cannot estimate	6.25^a	3.10-14.69	2.57^c	1.73-3.82
Grade
I	403	Cannot estimate	Reference		Reference
II	850	Cannot estimate	1.75	0.98-3.33	1.56	0.88-2.76
III/IV	538	Cannot estimate	15.48^a	9.17-28.16	4.35^c	2.52-7.52
Unknown	419	Cannot estimate	7.02^a	4.06-13.01	2.92^c	1.67-5.10
Race
American Indian/Alaska Native	16	Cannot estimate	1.24	0.33-3.20	4.29^c	2.18-8.48
Asian or Pacific Islander	206	Cannot estimate	0.64^b	0.41-0.96	0.79	0.52-1.19
Black	239	Cannot estimate	0.66^b	0.44-0.95	1.06	0.94-1.19
Unknown	23	Cannot estimate	0.00^b	0.00-0.90	Cannot estimate
White	1726	Cannot estimate	Reference		Reference
Sex
Female	1093	Cannot estimate	Reference		Reference
Male	1117	Cannot estimate	2.38^a	1.92-2.96	1.36^b	1.09-1.69
Radiation
No/unknown	1200	Cannot estimate	0.27^a	0.22-0.34	2.10	0.43-1.49
Yes	1010	Cannot estimate	Reference		Reference
Sequence
Not applicable	1260	Cannot estimate	Reference		Reference
Radiation after surgery	902	Cannot estimate	2.66^a	2.15-3.30	0.96	0.50-1.84
Radiation before surgery	48	Cannot estimate	2.79^c	1.55-4.70	1.05	0.47-2.33
Surgery
No	77	Cannot estimate	4.37^a	2.89-6.38	2.17^b	1.18-3.98
Unknown	28	74 ± 7.67	4.84^a	2.54-8.44	1.62^c	1.49-1.76
Yes	2105	Cannot estimate	Reference		Reference
Diagnosis year
1975-1995	960	Cannot estimate	1.40^b	1.14-1.73	1.33^b	1.03-1.72
1996-2016	1250	Cannot estimate	Reference		Reference
Surgery type					Variable not used in multivariate analysis
Excision	2085	Cannot estimate	Reference
Limited surgical procedure/biopsy	20	Cannot estimate	1.50	0.48-3.55
None	77	Cannot estimate	4.41^a	2.92-6.44
Unknown	28	74 ± 7.67	4.89^a	2.57-8.53
Diagnosis year					Variable not used in multivariate analysis
1975-1984	405	Cannot estimate	2.09^a	1.53-2.88
1985-1994	497	Cannot estimate	1.47^b	1.06-2.04
1995-2004	564	Cannot estimate	1.44^b	1.05-1.98
2005-2016	744	Cannot estimate	Reference

^aP < 0.0001.

^bP < 0.05.

^cP < 0.001.

Citation: Taylor ZC, Kaya EA, Bunn JD, Guss ZD, Mitchell BJ, Fairbanks RK, Lamoreaux WT, Wagner AE, Peressini BJ, Lee CM. Overall and cause-specific survival for mucoepidermoid carcinoma of the major salivary glands: Analysis of 2210 patients. World J Clin Oncol 2020; 11(12): 1029-1044
URL: https://www.wjgnet.com/2218-4333/full/v11/i12/1029.htm
DOI: https://dx.doi.org/10.5306/wjco.v11.i12.1029