Fibroblast growth factor receptor 4 single nucleotide polymorphism Gly388Arg in head and neck carcinomas

Table 1 Table of chi-square test of association between fibroblast growth factor receptor 4 genotype (Gly/Gly, Gly/Arg or Arg/Arg) and other pathological variables

	Fibroblast growth factor receptor 4 genotype				P-value
		Gly388	Arg388	n
Sex	Female	36	12	48	0.157
	Male	152	84	236
Age, mean (SD); sample size		54.20 (10.47); (188)	53.42 (10.46); (96)	284	0.55291
Survey outcome	Alive	80	44	124	0.598
	Dead	108	52	160
Histological grading	High	71	45	116	0.177
	Moderate	95	46	141
	Low	10	1	11
	No difference	12	4	16
Progression status	Positive	92	38	130	0.135
	Negative	96	58	154
Recurrence status	Negative	134	60	194	0.133
	Positive	54	36	90
Tumor size	T1	21	20	41	0.004
	T2	62	29	91
	T3	48	24	72
	T4	57	23	80
Lymph Nodes	N0	66	26	92	0.507
	N1	44	28	72
	N2	53	30	83
	N3	25	12	37
Metastases	M0	182	92	274	0.673
	M1	6	4	10

¹P-value from t-test for equality of means. NS indicates that the test result is not statistically significant.

Table 2 Genotypes in patients and controls of fibroblast growth factor receptor 4 and calculated probability of gene distribution in second rows n (%)

Fibroblast growth factor receptor 4 genotypes	Cancer cases (n = 284)	Controls (n = 123)
Gly/Gly	188 (66.2)	55 (45)
	0.65	0.47
Gly/Arg	84 (29.6)	60 (49)
	0.3	0.42
Arg/Arg	12 (4.2)	8 (6)
	0.03	0.09

Table 3 Table of chi-square test of association correlating fibroblast growth factor receptor 4 expression, lymph nodes and therapy

	Fibroblast growth factor receptor 4 expression
		low	high	n	P-value
Lymph nodes	N0, N1 and N2	479	459	938	0.0001
	N3	117	58	175
Chemotherapy	No	403	269	672	0.0001
	Yes	193	248	441

Table 4 Table of chi-square test of association between fibroblast growth factor receptor 4 genotypes (Gly/Gly and Gly/Arg or Arg/Arg), Lymph nodes, tumor stage, and recurrence status

	Fibroblast growth factor receptor 4 genotype
		Gly388	Arg388	n	P-value
Positive lymph nodes	N0, N1 and N2	644	295	939	0.010
	N3	75	17	92
Tumor stage	T1 and T2	491	86	577	0.0001
	T3 and T4	228	226	454
Recurrence status	0	574	208	782	0.0001
	1	145	104	249

Table 5 Results from Logistic regression of lymph node, tumor stage and recurrence status on fibroblast growth factor receptor 4 genotype (P < 0.0001)

Fibroblast growth factor receptor 4 genotype	Coeff.	Std. Err.	z	P >|z|	Odds ratio	95% CI
Recurrence status	0.440	0.1693179	2.6	0.009	4.37	0.1080489-0.7717629
positive lymph nodes	1.972	0.1585958	12.44	0.0001	14.43	1.661438-2.283122
Tumor stage	-1,721	0.2903174	-5.93	0.0001	0.24	-2.29047-1.152446
constant	-1.826	0.1234243	-14.79	0.0001		-2.067534-1.58372