Comparison of the eighth version of the American Joint Committee on Cancer manual to the seventh version for colorectal cancer: A retrospective review of our data

Figure 1 The progression of American Joint Committee on Cancer tumor staging. AJCC: American Joint Committee on Cancer.

Figure 2 Automatic linear regression about positive lymph nodes and clinicopathologic parameters with tumor-node-metastasis staging from AJCC-7^th. A: Clinical pathological parameters fitting degree. Fitting value is 61.3%; B: Significant effect parameters (P < 0.05); C: Predictor importance of positive lymph nodes and clinicopathological parameters. The values of tumor-node-metastasis staging from AJCC-7^th, tumor invasion, tumor size, and differentiation are 0.77, 0.19, 0.03, and 0.01, respectively; D: Coefficients about positive nodes and clinicopathological parameters.

Figure 3 Automatic linear regression about positive lymph nodes and clinicopathologic parameters with tumor-node-metastasis staging from AJCC-8^th. A: Clinical pathological parameters fitting degree. The fitting value is 63.3%; B: Significant effect parameters (P < 0.05); C: Predictor importance of positive lymph nodes and clinicopathological parameters. The values of tumor-node-metastasis staging from AJCC-8^th, tumor invasion, chemotherapy, tumor size, and differentiation are 0.72, 0.2, 0.04, 0.03 and 0.01, respectively; D: Coefficients about positive nodes and clinicopathological parameters.

Figure 4 Disease-free survival and overall survival curves and histograms between tumor-node-metastasis staging from AJCC-7^th and tumor-node-metastasis staging from AJCC-8^th. A: Comparison of 5-year disease-free survival (DFS) by sub-stage from AJCC-7^th (P < 0.001); B: Comparison of 5-year DFS by sub-stage from AJCC-8^th (P < 0.001); C: Comparison of 5-year overall survival (OS) by sub-stage from AJCC-7^th (P < 0.001); D: Comparison of 5-year OS by sub-stage for from AJCC-8^th (P < 0.001); E: Comparison of 5-year DFS by stage from AJCC-7^th (P < 0.001); F: Comparison of 5-year DFS by stage from AJCC-8^th (P<0.001); G: Comparison of 5-year OS by stage from AJCC-7^th (P < 0.001); H: Comparison of 5-year OS by stage for from AJCC-8^th (P < 0.001); A vs B and C vs D: Survival curves of DFS and OS in stage IVB shift right and those in stage IVC shift left; I-L: Comparison of DFS and OS by sub-stage and stage between staging from AJCC-7^th and staging from AJCC-8^th, all P < 0.01. DFS: Disease-free survival; OS: Overall survival; TNM: Tumor-node-metastasis.

Figure 5 The focus of the eighth edition of the American Joint Committee on Cancer pathology test description. A: Tumor deposit; B: Lymphatic invasion; C: Vein invasion; D: Nerve invasion.