Factors influencing response to ingenol mebutate therapy for actinic keratosis of face and scalp

Figure 1 Patient treated with ingenol mebutate for actinic keratosis of the scalp. A and C: Clinical images of the treated area before and after (day 57) the therapy, respectively; B: Local skin reaction to ingenol mebutate at day 8 showing a grade 3 crusting reaction and erythema exceeding the treated area (grade 4); D: Dermoscopic image of an actinic keratosis of the treated area at baseline showing red pseudonetwork and scaling in the central area; E: Dermoscopic picture of the same skin area at day 57 showing the complete disappearance of the preexisting actinic keratosis.

Figure 2 Number of skin reactions and scores at each follow up visit. A: The number and features of different skin reactions over the time; B: Mean values describing the severity of each skin reaction and the LSR composite score (light blue line). Skin reactions included: Erythema (blue), flaking/scaling (red), crusting (green), swelling (purple), vesiculation/pustulation (light blue), and ulceration (orange). LSR: Local skin reaction.