Translating new data to the daily practice in second line treatment of renal cell carcinoma: The role of tumor growth rate

Figure 1 Tumor growth rate calculation formula. TGR: Tumor-growth rate.

Figure 2 Hypothetical representation of different groups of patients and their patterns of response to first line treatment: Primary refractory patients with early progression and high tumor growth rate, intermediate progressors with intermediate tumor growth rate, very slow progressors with low tumor growth rate and late progressors with high tumor growth rate. TGR: Tumor-growth rate.

Figure 3 Adapting the study data to our clinic. A proposed algorithm to treat second line metastatic renal cell carcinoma patients according to tumor growth rate and patients’ characteristics. TGR: Tumor-growth rate; TKI: Tyrosine kinase inhibitor; LEN: Lenvatinib; EVE: Everolimus.