Better to be alone than in bad company: The antagonistic effect of cisplatin and crizotinib combination therapy in non-small cell lung cancer

Figure 1 Sensitivity of several non-small cell lung cancer cell lines to cisplatin (A) and crizotinib (B) monotherapy. Cells were exposed to the drugs for 72 h. Cisplatin and crizotinib concentrations are depicted in μmol/L. Values are means of at least 3 separate experiments. The maximal SEM was ± 9%.

Figure 2 Evaluation of the combination of cisplatin and crizotinib in non-small cell lung cancer cell lines using the fraction affected combination index method. A combination index > 1.2 is antagonistic. A: Growth curves of LUDLU-1 for cisplatin and crizotinib simultaneous treatment during 72 h; B: Combination Index vs Fraction affected for the LUDLU-1 cell line, treated simultaneously during 72 h with cisplatin and 5 μmol/crizotinib.