Comparative analysis of the effectiveness of abiraterone before and after docetaxel in patients with metastatic castration-resistant prostate cancer

Figure 1 Selection of randomized controlled trials included in the meta-analysis. RCTs: Randomized controlled trials.

Figure 2 Overall survival of abiraterone with prednisone vs placebo with prednisone. Hazard ratio (HR) associated with abiraterone with prednisone vs placebo with prednisone for overall survival, was calculated using fixed effects model. The HR and 95%CI for each trial and the final combined results are demonstrated numerically on the left and graphically as a forest plot on the right. For individual trials: filled in square, HR; lines, 95%CI; diamond plot, overall results of the included trials. OS: Overall survival.

Figure 3 Prostate specific antigen progression-free survival of abiraterone with prednisone vs placebo with prednisone. Hazard ratio (HR) associated with abiraterone with prednisone vs placebo with prednisone for PSA-PFS were calculated using fixed effects model. The HR and 95%CI for each trial and the final combined results are demonstrated numerically on the left and graphically as a forest plot on the right. For individual trials: filled in square, hazard ratio; lines, 95%CI; diamond plot, overall results of the included trials. PSA: Prostate specific antigen; PFS: Progression-free survival.

Figure 4 Radiographic progression-free survival of abiraterone with prednisone vs placebo with prednisone. Hazard ratio (HR) associated with abiraterone with prednisone vs placebo with prednisone for Radiographic-PFS were calculated using random effect model. The HR and 95%CI for each trial and the final combined results are demonstrated numerically on the left and graphically as a forest plot on the right. For individual trials: filled in square, hazard ratio; lines, 95%CI; diamond plot, overall results of the included trials. PFS: Progression-free survival.