Meta-regression of treatments for metastatic colorectal cancer: Quantifying incremental benefit from 2000 to 2012

Figure 1 Meta-regression: temporal trend of medians for overall survival (A) and progression-free survival (B). These graphs refer to 130 treatment arms from 52 randomized studies. The regression lines were the following: A:Median (mo) = 0.331 × yr - 674.138 (P < 0.001); B: Median (mo) = 0.2026 × yr - 399.538 (P < 0.001). Symbols: each study is represented by a circle, the area of which is proportional to its statistical weight. Experimental arms are depicted in red while control arms are in black. OS: Overall survival; PFS: Progression-free survival.