Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies

Figure 1 Molecular mechanisms through the Epidermal Growth Factor Receptor pathway. This figure shows EGFR ligands binding with their receptor and triggering mechanisms toward downstream intracellular signaling throughout the PLCγ, PI3K, Ras/Raf/MEK/ERK, STATs pathways leading to proliferation, metastasis, autocrine feedback, and survival (Adapted from reference 7 with permission). EGFR: Epidermal growth factor receptor; Shc: Src homologous and collagen protein; PCL-γ: Phospholipase Cγ; PI3K: Phosphatidylinositol 3-kinase; STATs: Signal transducer and activator of transcriptions; PKC: Protein kinase C; Grb2: Growth factor receptor bound protein 2; SOS: Guanine nucleotide exchange factor sos; MAPK:mitogen-activated protein kinase