Periampullary duodenal neuroendocrine tumor in a patient with neurofibromatosis-1: A case report

Figure 1 A view of the skin on the patient’s back. Numerous café-au-lait macules (the yellow arrows) and cutaneous neurofibromas (the blue arrows) can be seen.

Figure 2 Findings of the abdominal contrast-enhanced computed tomography scan. A: A tumor (the yellow arrow) 1.2 cm × 1.4 cm in the periampullary region, with progressive enhancement; B: Multiple hemangiomas (the yellow arrow) in the S8 segment of the liver; C: Localized thickening of the skin and subcutaneous tissue (the yellow arrow) in the lower anterior abdominal wall.

Figure 3 Microscopic findings of the pancreatic tumor. A: Histologic hematoxylin and eosin (HE) stain of the duodenal neuroendocrine tumor (NET) (magnification × 200); B and C: Expression of synaptophysin (B) and chromogranin A (C) were positive on immunohistochemical stain in the NET; D: Ki67 labeling index of the NET was 1%; E: Metastatic tumors in peripancreatic lymph nodes; F: HE stain of the stromal tumor in the serous surface of the duodenum; G and H: Expression of CD 117(G) and DOG-1 (H) were positive on immunohistochemical stain in the stromal tumor; I: HE stain of the cutaneous neurofibroma; J: Expression of S100 protein was positive in the neurofibroma (magnification × 200).

Figure 4 Number of publications by year.

Figure 5 Cooperative relationships between countries/regions. To make the plot more concise, the countries with frequencies less than 3 were deleted.

Figure 6 Treemap of the 50 most frequently occurring “Keywords Plus” terms in original articles on periampullary neuroendocrine neoplasms from 1998 to 2023.