Tyrosine kinase inhibitors and human epidermal growth factor receptor-2 positive breast cancer

Figure 1 Schematic representation of TKIs targeting EGFR and various HER family receptors, leading to the inhibition of downstream PI3K and MAPK pathway, resulting in the regulation of cell cycle progression and proliferation. ¹The sign denotes inhibition. The authors would like to acknowledge Biorender.com software that was used to create Figure 1.