How can we kill cancer cells: Insights from the computational models of apoptosis

Figure 1 Schematic representation of the apoptosis signaling pathway that indicates existence of three distinct signaling modules in the apoptotic intrinsic pathway. Apoptosis can be activated at various locations in the intrinsic pathway. We also show some of the targets of cancer drugs.

Figure 2 Time course of caspase-3 activation for low concentrations of caspase-8 (< 5 nmol). Data is shown for five individual cells. Arrows indicates switch to the intrinsic pathway of apoptosis at the level of single cells.