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World J Clin Oncol. Jul 10, 2012; 3(7): 104-110
Published online Jul 10, 2012. doi: 10.5306/wjco.v3.i7.104
Published online Jul 10, 2012. doi: 10.5306/wjco.v3.i7.104
Inhibition of N-Myc down regulated gene 1 in in vitro cultured human glioblastoma cells
Harun M Said, Buelent Polat, Mathias Guckenberger, Adrian Staab, Astrid Katzer, Michael Flentje, Dirk Vordermark, Department of Radiation Oncology, University of Wuerzburg, 97080 Würzburg, Germany
Susanne Stein, Department of Hematology and Oncology, Johannes Gutenberg University, III Medical School, 55101 Mainz, Germany
Carsten Hagemann, Jelena Anacker, Department of Neurosurgery, Tumorbiology Laboratory, University of Wuerzburg, 97080 Würzburg, Germany
Adrian Staab, Department of Radiation Oncology, Paul Scherer Institute, CH-5100 Villingen, Switzerland
Jelena Anacker, Department of Gynaecology and Obstetrics, University of Wuerzburg, 97080 Würzburg, Germany
Dirk Vordermark, Department of Radiation Oncology, University-Halle-Wittenberg, 06110 Halle, Germany
Author contributions: Said HM was the primary author of the manuscript, performed the in vitro hypoxia experiments, supplied the in vitro mRNA, protein lysates and nuclear extracts, performed the Western blotting, densitometric analysis of the results and participated in the study design; Polat B, Stein S, Guckenberger M and Hagemann C co-authored the manuscript and participated in the study design; Said HM, Stein S, Hagemann C and Vordermark D coordinated the group and contributed to the development of the experimental strategy; Anacker J designed the primers used for reverse transcription polymerase chain reaction and participated in the study design and evaluation; Said HM, Flentje M and Vordermark D also participated in the study design; all authors read and approved the manuscript.
Supported by Deutsche Forschungsgemeinschaft DFG, VO 871/2-3, to Vordermark D; and the IZKF Würzburg, B25, to Hagemann C
Correspondence to: Dr. Harun M Said, PhD, Department of Radiation Oncology, University of Würzburg, Josef-Schneider-Str. 11, 97080 Würzburg, Germany. said@scientist.com
Telephone: +49-163-7538317 Fax: +49-163-7531174
Received: August 30, 2011
Revised: December 10, 2011
Accepted: June 30, 2012
Published online: July 10, 2012
Revised: December 10, 2011
Accepted: June 30, 2012
Published online: July 10, 2012
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