Accelerated infliximab infusions for inflammatory bowel disease improve effectiveness

Table 1 Protocols developed for standard and accelerated infliximab infusions

Standard infliximab infusions		Accelerated infliximab infusions
120 min, 250 mL		90 min, 250 mL		60 min, 250 mL		90 min, 500 mL		60 min, 500 mL
Rates (mL/h)	Dose (mL)	Rates (mL/h)	Dose (mL)	Rates (mL/h)	Dose (mL)	Rates (mL/h)	Dose (mL)	Rates (mL/h)	Dose (mL)
10	2.5	10	2.5	20	2.5	20	5	50	5
20	5	20	5	40	5	40	10	100	10
40	10	40	10	80	10	80	20	350	40
80	20	80	20	160	20	300	40	500	80
150	75	500	190	300	75	700	420	750	350
250	135			550	135

Table 2 Characteristics of study participants

Characteristics	Data (%)
Gender	Female: 19/46 (41.3)
	Male: 27/46 (58.7)
Race	African American: 5/46 (10.9)
	Caucasian: 41/46 (89.1)
Age, yr	Mean: 42.6
	Median: 41.5
	Range: 21-89
Disease type	Ulcerative colitis: 9/46 (19.6)
	Crohn's: 37/46 (80.4)
Use of premedications	17/46 (37.0)
On corticosteroid therapy	1/46 (2.2)
On immunosuppressive therapy	10/46 (21.7)
Dose	5 mg/kg: 25/46 (54.3)
	7.5 mg/kg: 5/46 (10.9)
	10 mg/kg: 16/46 (34.8)
Number of infusions prior to accelerated protocol	Mean: 27.4
	Median: 22
	Range: 4-65
Body mass index	Normal (18.5-25.0): 19/46 (41.3)
	Low (< 18.5): 1/46 (2.2)
	High (> 25.0): 26/46 (56.5)

Table 3 Data for each individual study participant

No	Patient	Age (yr)	BMI	Dose1	Date		Diagnose	Diagnosis
					90 min infusion	60 min infusion3
1	Male: Caucasian	37	170lbs (77 kg)BMI = 21.83 kg/m2	22 infusions5 mg/kg per 8 wk	12/16/2011	02/20/2012	Ulcerative colitis	Tylenol 650 mgClaritin 10 mgSolucortef 100 mg
2	Male: Caucasian	56	202lbs (91 kg)BMI = 28.98 kg/m2	13 infusions7.5 mg/kg per 8 wk	04/02/2012		Crohn's disease
3	Male: Caucasian	39	146lbs (66 kg)BMI = 19.80 kg/m2	50 infusions10 mg/kg per 7 wk	12/19/2011	02/09/201203/29/2012	Crohn's disease	Hydrocortisone 100 mg
4NI	Female: African-American2	50	198lbs (89 kg)BMI = 31.01 kg/m2	22 infusions5 mg/kg per 7 wkHb = 12.3 g/dL			Crohn's disease
5	Male: Caucasian	28	203lbs (92 kg)BMI = 29.17 kg/m2	38 infusions5 mg/kgper 8 wk	09/27/2011	11/22/201101/23/201203/20/2012	Crohn's disease
6	Male: Caucasian	30	115lbs (52 kg)BMI = 15.60 kg/m2	6 infusions5 mg/kg per 8 wk			Crohn's disease
7	Female: Caucasian	53	300lbs (136.5 kg)BMI = 57.78 kg/m2	42 infusions5 mg/kg per 8wk	08/08/2011	10/11/201112/21/201102/13/2012	Crohn's disease (fistulizing)
8	Female: CaucasianMoved to Germany Dec 2011	21	121lbs (55 kg)BMI = 22.18 kg/m2	12 infusions5 mg/kg per 8wk	08/22/2011	10/17/201112/12/2011	Crohn's disease
9	Male: Caucasian	50	179lbs (81 kg)BMI = 27.25 kg/m2	8 infusions5 mg/kg per 6 wk	08/23/2011	10/04/201111/15/201112/27/201102/07/201203/21/2012	Crohn's disease
10	Male: Caucasian	47	195.8lbs (89 kg)BMI = 28.96 kg/m2	15 infusions10 mg/kg per 6 wk	11/08/2011	12/27/201102/06/201203/21/2012	Crohn's disease
11	Female: Caucasian	58	157lbs (71 kg)BMI = 23.87 kg/m2	62 infusions7.5 mg/kg per 7 wk	11/07/201112/29/201102/03/2012	04/02/2012	Crohn's disease
12	Female: CaucasianMoved to another hospital	55	200lbs (90 kg)BMI = 34.16 kg/m2	50 infusions7.5 mg/kg per 8 wk	09/26/2011	11/21/2011	Crohn's disease
13	Male: Caucasian	29	154lbs (70 kg)BMI = 21.50 kg/m2	40 infusions5 mg/kg 400 mg per 6 wkHb = 15.6g/dL	01/03/2012	02/14/201203/30/2012	Crohn's disease
14	Female: Caucasian	36	248lbs (113 kg)BMI = 35.87 kg/m2	16 infusions5 mg/kg600-7.5 mg/kg shortened infusion D/C	09/02/201110/28/2011Normal infusion time01/27/2012 (after dose increase)	03/23/2012	Ulcerative colitis
15	Female: Caucasian	34	167lbs (76 kg)BMI = 29.80 kg/m2	9 infusions5 mg/kg400 mg per 6-8wkHb = 12.1g/dL	07/28/2011	09/16/201111/02/201112/20/201102/09/201203/22/2012	Crohn's disease
16	Female: Caucasian	54	121lbs (54 kg)BMI = 20.14 kg/m2	48 infusions5 mg/kg per 8 wk	03/05/2012		Crohn's disease
17	Female:African-American	68	191lbs (87 kg)BMI = 33.71 kg/m2	30 infusions 10 mg/kg per 4 wk	11/23/2011	12/22/201101/16/201202/17/201203/16/2012	Crohn's disease
18	Female: Caucasian	25	146lbs (66 kg)BMI = 22.87 kg/m2	Since 20055 mg/kg per 8 wk	01/05/201203/01/2012		Crohn's disease
19	Female: Caucasian	56	145lbs (66 kg)BMI = 22.87 kg/m2	51 infusions10 mg/kg per 5 wk	10/21/2011	12/02/201201/13/201202/17/201203/30/2012	Crohn's disease
20	Female: Caucasian	26	143lbs (65 kg)BMI = 23.85 kg/m2	10 infusions5 mg/kg per 7 wk	07/25/2011	09/23/201111/10/201101/05/201202/23/2012	Crohn's disease
21	Male: Caucasian	47	199lbs (90 kg)BMI = 22.75 kg/m2	48 infusions10 mg/kg per 6 wk	12/20/2011	01/31/201202/12/2012	Ulcerative colitis
22	Female: Caucasian	36	232lbs (105 kg)BMI = 35.28 kg/m2	5 infusions10 mg/kg,1100 mg in 500 mL per 6 wk	01/13/201202/24/2012	04/06/2012	Crohn’s disease
23	Male: Caucasian	21	202 lbs (91 kg)BMI = 27.40 kg/m2	4 infusions5 mg/kg per 8 wk	01/23/2012	03/21/2012	Crohn’s disease
24	Female: Caucasian	41	126lbs (57.5 kg)BMI = 19.86 kg/m2	14 infusions10 mg/kg per 8 wk	02/22/2012	04/12/2004	Crohn’s disease
25	Male: CaucasianTransferred receives remicade locally (01/31/12)	34	212lbs (96.8 kg)BMI = 32.46 kg/m2	24 infusions5 mg/kg per 8 wk	08/11/2011	10/07/201112/02/2011	Ulcerative colitis
26	Male: Caucasian	41	196lbs (88 kg)BMI = 32.62 kg/m2	21 infusions10 mg/kg per 6 wk	04/04/2012		Crohn’s disease
27	Male: Caucasian	63	176lbs (80 kg)BMI = 26.76 kg/m2	61 infusions5 mg/kg 400 mg	09/08/2011	11/29/201101/27/201203/14/2012	Crohn’s disease
28	Male: Caucasian	38	149lbs (67.5 kg)BMI = 22.00 kg/m2	10 infusions10 mg/kg per 6 wk	12/08/2011	01/20/201203/06/2012	Crohn’s disease
29	Female: Caucasian	42	259lbs (117.5 kg)BMI = 41.80 kg/m2	46 infusions10 mg/kg1200 mg in 500 mL	02/13/2012	04/02/2012	Crohn’s disease
30	Male: Caucasian	40	192LBS (87 kg)BMI = 27.55 kg/m2	65 infusions7.5 mg/kg per 8 wk`	12/13/2011	02/07/2012	Crohn’s disease
32	Male: Caucasian	49	154LBS (70 kg)BMI = 23.42 kg/m2	49 infusions10 mg/kg700 mg per 8wk	12/19/2011	02/10/2012	Crohn’s disease
33	Male: Caucasian	23	131lbs (59.5 kg)BMI = 18.83 kg/m2	15 infusions10 mg/kg per 8 wk	01/11/2012	03/09/2012	Ulcerative colitis
34	Male: Caucasian	26	208lbs (94.5 kg)BMI = 26.71	7 infusions5 mg/kg per 8 wk	09/12/2011	11/07/201101/03/201203/27/2012	Crohn’s disease
35	Female: African-American	24	129lbs (58.5 kg)BMI = 22.14 kg/m2	11 infusions7.5 mg/kg per 8 wkHb = 13.1 g/dL	01/23/2012	03/20/2012	Crohn’s disease
36	Male: Caucasian	31	170lbs (77 kg)BMI = 23.11 kg/m2	13 infusions5 mg/kg per 8 wk Normal infusion on 02/21 because of dose increase: 600 mg	11/14/2011	01/16/2012	Crohn’s disease
37	Male: African-American	45	267lbs (121 kg)BMI = 40.60 kg/m2	27 infusions10 mg/kg1200 mg in 500 mL per 7 wk	12/15/201102/15/201204/05/2012		Crohn’s disease
38	Male: Caucasian	89	184lbs (83.5 kg)BMI = 27.17 kg/m2	22 infusions5 mg/kg per 8 wk	07/21/2011	09/15/201111/03/201112/29/201102/23/2012	Crohn’s disease
39	Male: Caucasian	46	181lbs (82 kg)BMI = 22.62 kg/m2	24 infusions10 mg/kg per 5 wk	11/29/2011	01/10/201202/14/201203/20/2012	Crohn’s disease
40	Male: Caucasian	58	167lbs (76 kg)BMI = 27.79 kg/m2	19 infusions5 mg/kg per 8 wk	09/12/2011	11/07/201101/09/201203/05/2012	Ulcerative colitis
41	Male: Caucasian	72	169lbs (77 kg)BMI = 25.81 kg/m2	23 infusions 10 mg/kg per 7 wk	11/19/2011	01/06/201202/24/2012	Ulcerative colitis
42	Female: Caucasian	48	128lbs (58 kg)BMI = 22.32 kg/m2	54 infusions5 mg/kg per 6 wk	09/30/2011	11/23/201101/17/201203/23/2012	Crohn’s disease
43	Caucasian30 yr old	30	264lbs (120 kg)BMI = 35.88 kg/m2	44 infusions5 mg/kg per 8 wk	08/04/2011	09/29/201111/28/201101/23/201203/19/2012	Crohn’s disease
44	Female:Caucasian	44	138lbs (63 kg)BMI = 21.7 kg/m2	54 infusions10 mg/kg per 5 wk	01/26/2012	03/01/201204/05/2012	Crohn’s disease
45	Male: Caucasian	28	205lbs (93 kg)BMI = 27.80 kg/m2	10 infusions5 mg/kg per 8 wk	01/26/2012	03/21/2012	Ulcerative colitis
46	Male: African-American	43	277lbs (103 kg)BMI = 36.65 kg/m2	5 infusions5 mg/kg per 8 wk	08/19/2011	10/10/201112/05/201101/18/201202/27/2012	Crohn’s disease
47	Female: Caucasian	50	202lbs (92 kg)BMI = 34.81 kg/m2	7 infusions5 mg/kg per 6 wk	07/21/2011	09/01/201110/10/201111/21/201112/29/201102/06/201203/19/2012	Ulcerative colitis

¹Dose + numbers of remicade treatments at the time of the 1st shortened infusion + infusion frequency;

²After initial accept, the patient changed her mind and withdrew;

³1st 60 min infusion + subsequent 60 min. NI: Not included; BMI: Body mass index.