Capsaicin-sensitive afferentation represents an indifferent defensive pathway from eradication in patients with H. pylori gastritis

doi:10.4292/wjgpt.v2.i5.36

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Oct 6, 2011 (publication date) through Dec 22, 2024

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pharmacol Ther. Oct 6, 2011; 2(5): 36-41
Published online Oct 6, 2011. doi: 10.4292/wjgpt.v2.i5.36

Table 1 Detailed information of antibodies used

Antisera	Abbreviation	Species	Dilution	Source
Calcitonin gene-related peptide	CGRP	Rabbit polyclonal	1:100	Abcam, Cambridge, UK
Substance P	SP	Rat monoclonal	1:200	Abcam, Cambridge, UK
Transient receptor potential vanilloid 1	TRVP1	Rabbit polyclonal	1:1000	Abcam, Cambridge, UK

CGRP: Calcitonin gene-related peptide; SP: Substance P; TRVP1: Transient receptor potential vanilloid 1.

Table 2 Summary of the presence of capsaicin receptor, calcitonin gene-related peptide and substance P in the gastric mucosa of patients with chronic Helicobacter pylori positive gastritis, before and after eradication therapy, obtained by immunohistochemistry n (%)

	TRVP1		CGRP		Substance P
	Positive	Negative	Positive	Negative	Positive	Negative
Before eradication (n = 18)	16 (88.89)	2 (11.11)	18 (100)	0 (0)	1 (5.56)	17 (94.44)
After eradication (n = 18)	13 (72.22)	5 (17.78)	18 (100)	0 (0)	0 (0)	18 (100)
Control group (n = 20)	7 (35)	13 (65)	8 (40)	12 (60)	15 (75)	5 (25)

CGRP: Calcitonin gene-related peptide; TRVP1: Transient receptor potential vanilloid 1.

Citation: Lakner L, Dömötör A, Tóth C, Szabó IL, Meczker &, Hajós R, Kereskai L, Szekeres G, Döbrönte Z, Mózsik G. Capsaicin-sensitive afferentation represents an indifferent defensive pathway from eradication in patients with H. pylori gastritis. World J Gastrointest Pharmacol Ther 2011; 2(5): 36-41
URL: https://www.wjgnet.com/2150-5349/full/v2/i5/36.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v2.i5.36