Histopathological evaluation of long-term tenofovir disoproxil fumarate treatment in patients with hepatitis be antigen-negative chronic hepatitis B

Table 1 Demographics of the patients before and after treatment

		mean ± SD	P value
Age		47.9 ± 10.4
Male		27 (54%)
Treatment period (wk)		60.8 ± 9.7
AST	BT	82.3 ± 218.6	< 0.001
	AT	23.7 ± 14.1
ALT	BT	74.3 ± 118.1	< 0.001
	AT	23.7 ± 14.1
T.Bil.	BT	0.8 ± 0.4	0.024
	AT	0.8 ± 1
Albumin	BT	3.9 ± 0.7	> 0.5
	AT	4 ± 0.8
Creatine	BT	1 ± 1.98	> 0.5
	AT	0.8 ± 0.2
PLT	BT	208000 ± 55000	0.007
	AT	238000 ± 78000
Ishak score	BT	2.2 ± 1.4	0.002
	AT	1.3 ± 1.3
HAI score	BT	7.2 ± 3.2	< 0.001
	AT	4.1 ± 2.8

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBIL: Total bilirubin; PLT: Platelets; HAI: Histology activity index; BT: Before treatment; AT: After treatment.