Interaction of insulin with prokinetic drugs in STZ-induced diabetic mice

Figure 1 Acute effect in streptozotocin-induced diabetic mice of single doses of insulin, metoclopramide, domperidone and erythromycin individually as well as the combination of insulin with metoclopramide, domperidone or erythromycin. A: Blood glucose level; B: Serum insulin level. Values represent the mean ± SE of eight mice per group. Significantly different from the normal control value at ^aP < 0.05; Significantly different from the diabetic control value at ^cP < 0.05; Significantly different from insulin value at ^eP < 0.05.

Figure 2 Subchronic effect in streptozotocin-induced diabetic mice of one week of daily administration of insulin, metoclopramide, domperidone and erythromycin individually as well as the combination of insulin with metoclopramide, domperidone or erythromycin. A: Blood glucose level; B: Serum insulin level. Values represent the mean ± SE of eight mice per group. Significantly different from the normal control value at ^aP < 0.05; Significantly different from the diabetic control value at ^cP < 0.05; Significantly different from insulin value at ^eP < 0.05.

Figure 3 Effect on oral D-xylose absorption and tolerance test in streptozotocin-induced diabetic mice of single doses of insulin, metoclopramide, domperidone and erythromycin individually as well as the combination of insulin with metoclopramide, domperidone or erythromycin. A: Oral D-xylose absorption test; B: Oral D-glucose tolerance test. Values represent the mean ± SE of eight mice per group. Significantly different from the normal control value at ^aP < 0.05; Significantly different from the diabetic control value at ^cP < 0.05; Significantly different from insulin value at ^eP < 0.05.

Figure 4 Effect on the area under the curve of blood glucose concentrations during oral glucose absorption test in streptozotocin-induced diabetic mice of single doses of insulin, metoclopramide, domperidone and erythromycin individually as well as the combination of insulin with metoclopramide, domperidone or erythromycin. Values represent the mean ± SE of eight mice per group. Significantly different from the normal control value at ^aP < 0.05; Significantly different from the diabetic control value at ^cP < 0.05; Significantly different from insulin value at ^eP < 0.05. AUC: Areas under the curve.