Insights of gut-liver axis in hepatic diseases: Mechanisms, clinical implications, and therapeutic potentials

doi:10.4292/wjgpt.v15.i6.98146

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Nov 5, 2024 (publication date) through Nov 20, 2024

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pharmacol Ther. Nov 5, 2024; 15(6): 98146
Published online Nov 5, 2024. doi: 10.4292/wjgpt.v15.i6.98146

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Figure 1 Role of gut microbiota in maintaining liver homeostasis. IgA: Immunoglobulin A; IL: Interleukin; MAMP: Microbe-associated molecular patterns; PAMP: Pathogen-associated molecular patterns; TGF: Transforming growth factor; TNF: Tumor necrosis factor.

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Figure 2 Dysbiotic gut-liver axis resulting in liver damage. IL: Interleukin; LPS: Lipopolysaccharide; M: Macrophage; KCs: Kupffer cells; DAMP: Damage-associated molecular patterns; PAMP: Pathogen-associated molecular patterns; TNF: Tumor necrosis factor.

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Figure 3 Therapeutic potential of intestinal microbiome in liver disease management.

Citation: Jeyaraman N, Jeyaraman M, Mariappan T, Muthu S, Ramasubramanian S, Sharma S, Santos GS, da Fonseca LF, Lana JF. Insights of gut-liver axis in hepatic diseases: Mechanisms, clinical implications, and therapeutic potentials. World J Gastrointest Pharmacol Ther 2024; 15(6): 98146
URL: https://www.wjgnet.com/2150-5349/full/v15/i6/98146.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v15.i6.98146