Alcoholic hepatitis: The pivotal role of Kupffer cells

Table 1 Randomized controlled trials evaluating the treatment of alcoholic hepatitis

Study	Topic	Methods	Findings
Prednisolone or pentoxifylline
Theodossi et al[99]	PRED vs placebo	Randomized control	No difference in mortality
Ramond et al[100]	PRED vs placebo	Double-blinded, randomized control	Improved mortality with PRED
Akriviadis et al[69]	PTX vs placebo	Double-blinded, randomized control	Improved mortality with PTX
Sidhu et al[101]	PTX vs placebo	Randomized control	Improved mortality with PTX
De et al[102]	PTX vs PRED	Double-blinded, randomized control	Reduced mortality with PTX
Park et al[103]	PTX vs PRED	Randomized control	Reduced mortality with PRED
Mathurin et al[104]	PRED vs PRED + PTX	Multicenter, double-blinded, randomized control	No difference in mortality
De et al[105]	PTX vs PTX + PRED	Double-blinded, randomized control	No difference in mortality
Thursz et al[70]	PTX vs PRED vs placebo	Multicenter, double-blinded, randomized control	No difference in mortality
N-acetylcysteine
Moreno et al[106]	NAC vs placebo	Multicenter, single-blinded, randomized control	No difference in mortality
Cytokine inhibitors
Naveau et al[72]	Infliximab vs placebo	Double-blinded, randomized control	Increased mortality with infliximab
Boetticher et al[71]	Etancercept vs placebo	Multicenter, single-blinded, randomized control	Increased mortality with etancercept

PTX: Pentoxifylline; PRED: Prednisiolone; NAC: N-acetylcysteine.