Cancer stem cells in Helicobacter pylori infection and aging: Implications for gastric carcinogenesis

doi:10.4291/wjgp.v5.i3.366

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Aug 15, 2014 (publication date) through Nov 3, 2024

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. Aug 15, 2014; 5(3): 366-372
Published online Aug 15, 2014. doi: 10.4291/wjgp.v5.i3.366

Table 1 Staining scores for stem cell markers in human gastric mucosa and rat gastric mucosa

	n	ALDH	CD166	LGR5
Normal	10	1-2	0	1-2
H. pylori without IM	12	5-6^a	3-4^a	3-4^a
H. pylori with IM	10	7-8^a	5-6^a	5-6^a
Gastric adenocarcinoma	12	85%	75%	70%
4-mo-old rat	6	1-2	1-2	0
24-mo-old rat	6	3-4	5-6^a	3-4^a

The numbers are cells expressing the marker per a crypt counted. We grouped the cell counts as 0; 1-2; 3-4; 5-6; 7-8; etc. For evaluation of gastric adenocarcinoma, we expressed the percentage of cells staining with the related marker.

^aP < 0.05 vs normal human gastric mucosa or 4-mo-old rat gastric mucosa. Gastric adenocarcinoma was not included in statistical analysis.

Citation: Levi E, Sochacki P, Khoury N, Patel BB, Majumdar AP. Cancer stem cells in Helicobacter pylori infection and aging: Implications for gastric carcinogenesis. World J Gastrointest Pathophysiol 2014; 5(3): 366-372
URL: https://www.wjgnet.com/2150-5330/full/v5/i3/366.htm
DOI: https://dx.doi.org/10.4291/wjgp.v5.i3.366