Wang AH, Liu Y, Wang B, He YX, Fang YX, Yan YP. Epidemiological studies of esophageal cancer in the era of genome-wide association studies. World J Gastrointest Pathophysiol 2014; 5(3): 335-343 [PMID: 25133033 DOI: 10.4291/wjgp.v5.i3.335]
Corresponding Author of This Article
An-Hui Wang, Associate Professor, Department of Epidemiology, School of Public Health, Fourth Military Medical University, No. 169 Changle West Road, Xi’an 710032, Shaanxi Province, China. wanganhui@hotmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 3 MicroRNA expression and their associations with esophageal squamous cell carcinoma[45]
MiRNA
Compared to normal esophageal tissue
Proved targets
miR-10a
Decreased
HOXA3, HOXB1, HOXB3
HOXD4, HOXD10
miR-21
Increased
PCDCD4, NFIB, PTEN, TPM1
miR-93
Increased
FUSA, E2F1, TP53, INP1
miR-129
Increased
LATS2
miR-203
Increased/ decreased
ABL1, TP53INP1, SOCS3
miR-205
Decreased/increased
ZEB1, ZEB2, E2F5, HER3, ERBB3, PRKCE, LRP1
miR-375
Decreased
PDK1
Table 4 Common miRNA expression profiles in esophageal cancer[47]
ESCC
EAC
Up-regulated
Down-regulated
Up-regulated
Down-regulated
miR-21
Let-7c
miR-21
Let-7c
miR-155
miR-1
miR-28
miR-203
miR-93
MiR-99a
miR-3a-5p
miR-205
miR-129
miR-100
miR-143-145 cluster
miR-23a
miR-133a
miR-192
miR-27a
miR-143-145 cluster
miR-194
miR-27b
miR-203
miR-215
miR-31
miR-375
miR-99a
miR-100
Citation: Wang AH, Liu Y, Wang B, He YX, Fang YX, Yan YP. Epidemiological studies of esophageal cancer in the era of genome-wide association studies. World J Gastrointest Pathophysiol 2014; 5(3): 335-343