Stimulation of oval cell and hepatocyte proliferation by exogenous bombesin and neurotensin in partially hepatectomized rats

doi:10.4291/wjgp.v2.i6.146

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 2, Issue 6

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3733)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series, Tables (1-3) series.

Item

Count

PDF

339

HTML

2900

Figures (1-2)

234

Tables (1-3)

260

Sum=3733

Dec 15, 2011 (publication date) through Dec 2, 2024

Times Cited of This Article

Times Cited (5)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Pathophysiology

ISSN

2150-5330

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Original Article

World J Gastrointest Pathophysiol. Dec 15, 2011; 2(6): 146-154
Published online Dec 15, 2011. doi: 10.4291/wjgp.v2.i6.146

Table 1 Portal Endotoxin concentrations and hepatic glutathione redox state (mean ± SD)

Markers	Control (I) (n = 10)	Sham (II) (n = 15)	PHx (III) (n = 15)	PHx + BBS (IV) (n = 15)	PHx + NT (V) (n = 15)
Endotoxin (EU/mL)	0.41 ± 0.07	0.40 ± 0.10	2.45 ± 0.62^a	1.36 ± 0.53^b	1.59 ± 0.44^b
GSH: GSSG	11.55 ± 3.40	12.02 ± 2.85	20.43 ± 4.64^a	25.88 ± 5.27^c	28.69 ± 5.94^b

^aP < 0.001 vs sham;

^bP < 0.001 vs partial hepatectomy (PHx);

^cP < 0.05 vs PHx. BBS: Bombesin; NT: Neurotensin. GSH: Reduced glutathione hormone; GSSG: Oxidized glutathione.

Table 2 Morphometric analysis of oval cell presence and proliferation (marker-positive oval cells per high power field) (mean ± SD)

Markers	Control (I) (n = 10)	Sham (II) (n = 15)	PHx (III) (n = 15)	PHx + BBS (IV) (n = 15)	PHx + NT (V) (n = 15)
CK19 protein	1.65 ± 0.31	1.63 ± 0.28	6.22 ± 0.82^a	18.51 ± 2.31^b	19.37 ± 3.48^b
AFP mRNA	1.34 ± 0.25	1.31 ± 0.21	5.45 ± 0.91^a	16.32 ± 1.81^b	17.53 ± 4.12^b
Ki67 protein	1.28 ± 0.14	1.26 ± 0.11	5.22 ± 0.11^a	15.61 ± 2.54^b	16.64 ± 3.59^b

^aP < 0.001 vs sham;

^bP < 0.001 vs partial hepatectomy (PHx). BBS: Bombesin; NT: Neurotensin; AFP: α-fetoprotein.

Table 3 Hepatocytes’ proliferation and apoptosis (mean ± SD)

Markers	Control (I) (n = 10)	Sham (II) (n = 15)	PHx (III) (n = 15)	PHx + BBS (IV) (n = 15)	PHx + NT (V) (n = 15)
Proliferation index	5.95 ± 1.33	6.12 ± 1.64	18.32 ± 3.11^a	27.25 ± 4.13^b	25.62 ± 3.41^b
Apoptotic index	0	0	19.31 ± 4.16^a	9.24 ± 2.65^b	8.97 ± 4.14^b
Proliferation/apoptosis	-	-	0.94 ± 0.74	2.99 ± 1.55^b	2.85 ± 0.82^b

^aP < 0.001 vs sham;

^bP < 0.001 vs partial hepatectomy (PHx). BBS: Bombesin; NT: Neurotensin.

Citation: Assimakopoulos SF, Tsamandas AC, Alexandris IH, Georgiou C, Vagianos CE, Scopa CD. Stimulation of oval cell and hepatocyte proliferation by exogenous bombesin and neurotensin in partially hepatectomized rats. World J Gastrointest Pathophysiol 2011; 2(6): 146-154
URL: https://www.wjgnet.com/2150-5330/full/v2/i6/146.htm
DOI: https://dx.doi.org/10.4291/wjgp.v2.i6.146