Gene and cell therapy based treatment strategies for inflammatory bowel diseases

Table 1 Overview of the gene therapy based treatment strategies for inflammatory bowel diseases as discussed in this review

	Viral vector	Gut targeting	Reference for gut targeting	Status of development	Reference for status of development
Gene therapy	Retro- and lentiviral	Yes	[24-27]	Not performed	N/A
	Adenoviral	Yes	[28-30]	Preclinical	[28-30]
	AAV	Yes	[31,32]	Not performed	N/A

The status of development refers to research which has already been performed. AAV: Adeno-associated virus; N/A: Not applicable.

Table 3 Overview of the combined gene and cell therapy based treatment strategies for inflammatory bowel diseases as discussed in this review

	Applied strategy	Viral vector used	Reference for viral vector used	Status of development	Reference for status of development
Combined gene and cell therapy	Ex vivo generated Treg/Tr1	Retrovirus	[113,115]	Preclinical	[113,115]
	T cell receptor transgenic Treg	Retrovirus	[116]	Preclinical	[116]

The status of development refers to research which has already been performed. Treg: CD4⁺CD25^highFOXP3⁺ regulatory T cell; Tr1: Type 1 regulatory T cell.