Link between irritable bowel syndrome, depression, and colorectal cancer risk in young patients: Age-matched nationwide population-based study

Table 1 Age matched (1:1) young (18-44 years) depressed cohort with vs without irritable bowel syndrome, 2019

Variables	Total young admissions with depression, n (%)		P value
	IBS- (n = 14370)	IBS+ (n = 14370)
Age (years) at admission	36 (29-41)	36 (29-41)	1
Median (IQR)
Sex
Male	34.20	16.10	< 0.001
Female	65.80	83.90
Race
White	67.00	80.80	< 0.001
Black	16.10	11.00
Hispanic	11.40	5.60
Asian or Pacific Islander	1.40	0.60
Native American	1.00	0.40
Others	3.20	1.70
Median household income national quartile for patient ZIP Code
0-25th	32.00	25.90	< 0.001
26-50th	26.10	25.70
51-75th	24.00	27.30
76-100th	17.90	21.10
Primary expected payer
Medicare	13.90	15.00	< 0.001
Medicaid	40.10	31.20
Private including HMO	34.60	45.40
Location/teaching status of hospital
Rural	7.70	7.40	0.029
Urban non-teaching	14.90	16.00
Urban teaching	77.50	76.60
Comorbidities
Acquired immune deficiency syndrome	1.00	0.40	< 0.001
Arthropathies	3.90	6.20	< 0.001
Dementia	0.30	0.10	0.001
Hypertension, complicated	7.90	6.40	< 0.001
Hypertension, uncomplicated	21.30	23.00	0.001
Diabetes with chronic complications	9.70	9.70	1
Diabetes without chronic complications	6.50	6.90	0.193
Hyperlipidemia	12.00	14.60	< 0.001
Obesity	23.60	27.70	< 0.001
Peripheral vascular disease	1.30	1.60	0.014
Prior MI	1.70	0.70	< 0.001
Chronic pulmonary disease	16.30	26.10	< 0.001
Hypothyroidism	7.80	11.20	< 0.001
Other thyroid disorders	1.10	2.00	< 0.001
Prior TIA/Stroke without Neurologic deficit	2.10	2.50	0.017
Prior VTE	5.00	5.80	0.002
Cancer	2.20	2.00	0.409
Anxiety and fear related disorders	54.60	68.60	< 0.001
Psychoses	4.20	4.50	0.312
Bipolar disorder	0.70	1.50	< 0.001
Borderline personality disorder	1.90	2.90	< 0.001
Alcohol abuse	12.00	6.30	< 0.001
Tobacco use disorder	32.80	26.10	< 0.001
Drug abuse	17.80	11.20	< 0.001

IBS: Irritable bowel syndrome; MI: Myocardial infarction; TIA: Transient ischemic attack; VTE: Venous thromboembolism.

Table 2 Prevalence and risk of colorectal cancer in age matched (1:1) young (18-44 years) depressed irritable bowel syndrome + vs irritable bowel syndrome-cohort 2019

	IBS- (n = 14370)	IBS+ (n = 14370)	P value
Rate of CRC	0.2%	0.2%	0.196
Logistic regression models	Odds ratio	95%CI (LL-UL)	Adjusted P value
Model 1-Univariate	0.71	0.23-2.25	0.565
Model 2-Adjusted for baseline sociodemographic characteristics + hospital characteristics	0.73	0.22-2.41	0.610
Model 31-Model 2 + relevant preexisting comorbidities	0.89	0.21-3.83	0.871

¹Adjusted for baseline sociodemographic and hospital characteristics like age, sex, race, median household income quartile, hospital location/teaching status, region, acquired immunodeficiency syndrome, drug abuse, alcohol abuse, tobacco use disorder, anxiety, bipolar disorder, borderline personality disorder, and psychoses, arthropathies, hypertension, diabetes, hyperlipidemia, obesity, peripheral vascular disease, prior myocardial infarction, and cancer.

IBS: Irritable bowel syndrome; CRC: Colorectal cancer.