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©The Author(s) 2022.
World J Gastrointest Pathophysiol. Jul 22, 2022; 13(4): 114-123
Published online Jul 22, 2022. doi: 10.4291/wjgp.v13.i4.114
Published online Jul 22, 2022. doi: 10.4291/wjgp.v13.i4.114
Table 1 Baseline characteristics of patients with Crohn’s disease
Characteristic | Frequency (n = 108) |
Age (yr) | 37.5 + 12.7 |
Sex (females) | 46 (42.6%) |
Age at diagnosis | |
< 17 yr | 7 (6.5%) |
17-40 yr | 75 (69.4%) |
> 40 yr | 26 (24.1%) |
Disease behaviour | |
Inflammatory | 43 (39.8%) |
Stricturing | 48 (44.4%) |
Penetrating | 13 (12.1%) |
Stricturing and penetrating | 4 (3.7%) |
Disease location | |
Ileal | 49 (45.4%) |
Colonic | 16 (14.8%) |
Ileo-colonic | 42 (38.9%) |
Upper gastrointestinal | 1 (0.9%) |
Perianal disease (Yes) | 15 (13.9%) |
Surgery for Crohn’s disease (Yes) | 37 (34.3%) |
Extra-intestinal manifestations (Yes) | 19 (17.6%) |
Smoking (Yes) | 12 (11.1%) |
Table 2 Frequency of the single nucleotide polymorphisms in protein tyrosine phosphate non-receptor type 2 gene in cases and controls
PTPN2 SNP rs7234029 | |||
Homozygote (GG) | Heterozygote (AG) | Wild type (AA) | |
Cases (n = 108) | 8 (7.4%) | 30 (27.8%) | 70 (64.8%) |
Controls (n = 98) | 5 (5.1%) | 44 (44.9%) | 49 (50%) |
P value1 | 0.05 | ||
PTPN2 SNP rs2542151 | |||
Homozygote (GG) | Heterozygote (GT) | Wild type (TT) | |
Cases (n = 101) | 4 (4%) | 40 (39.6%) | 57 (56.4%) |
Controls (n = 100) | 4 (4%) | 43 (43%) | 53 (53%) |
P value1 | 0.73 |
Table 3 Minor allele frequency of the single nucleotide polymorphisms in protein tyrosine phosphate non-receptor type 2 gene in cases and controls
Minor allele | Cases | Controls | P value | |
rs7234029 | G | 20.9% | 27.6% | 0.17 |
rs2542151 | G | 23.8% | 25.5% | 0.77 |
Table 4 Association of the single nucleotide polymorphisms in protein tyrosine phosphate non-receptor type 2 gene with patient and disease characteristics
Characteristic | rs7234029 | rs2542151 | |||||
Variant (n=38, GG or GA) | Wild type (n=70, AA) | P value | Variant (n=44, GG or GT) | Wild type (n=57, TT) | P value | ||
Sex | Female | 37% | 63% | 0.74 | 38.1% | 61.9% | 0.46 |
Male | 33.9% | 66.1% | 47.5% | 52.5% | |||
Age at onset of illness (yr) | Up to 40 yr | 39% | 61% | 0.21 | 43.4% | 56.6% | 0.96 |
> 40 | 23.1% | 76.9% | 44% | 56% | |||
Disease behaviour | NSNP | 29.6% | 70.4% | 0.42 | 45% | 55% | 0.98 |
SP | 39.1% | 60.9% | 42.6% | 57.4% | |||
Disease location | Ileal | 34.7% | 65.3% | 0.98 | 42.9% | 57.1% | 0.28 |
Colonic | 35.3% | 64.7% | 23.5% | 76.5% | |||
Ileocolonic | 36.6% | 63.4% | 43.9% | 56.1% | |||
Perianal disease | Present | 46.7% | 53.3% | 0.32 | 46.7% | 53.3% | 0.79 |
Absent | 33.3% | 66.7% | 43% | 57% | |||
Surgery for Crohn’s disease | Yes | 32.4% | 67.6% | 0.67 | 29.4% | 70.6% | 0.07 |
No | 36.6% | 63.4% | 50.1% | 49.9% | |||
Smoking | Yes | 25% | 75% | 0.43 | 41.7% | 58.3% | 0.89 |
No | 36.5% | 63.5% | 43.8% | 56.2% | |||
EIM | Yes | 40% | 60% | 0.62 | 29.4% | 70.6% | 0.31 |
No | 34.1% | 65.9% | 46.4% | 53.6% |
- Citation: Chatterjee K, Dutta AK, Goel A, Aaron R, Balakrishnan V, Thomas A, John A, Jaleel R, David D, Kurien RT, Chowdhury S, Simon EG, Joseph A, Premkumar P, Pulimood AB. Common polymorphisms of protein tyrosine phosphate non-receptor type 2 gene are not associated with risk of Crohn’s disease in Indian. World J Gastrointest Pathophysiol 2022; 13(4): 114-123
- URL: https://www.wjgnet.com/2150-5330/full/v13/i4/114.htm
- DOI: https://dx.doi.org/10.4291/wjgp.v13.i4.114